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Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

Promoting Self-Management in Head and Neck Cancer Survivors With Lymphedema and Fibrosis [PROMISE Trial]

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* \>18 years of age
* Post HNC primary treatment
* No evidence of cancer (NED)
* Completion of initial lymphedema therapy for head and neck lymphedema
* Unable to obtain lymphedema therapy due to barriers noted above
* History of lymphedema on the face and neck, with or without fibrosis
* Ability to understand English in order to complete questionnaires
* Ability to perform self-care activities for LEF management
* Ability to provide informed consent
* Having an electronic device (a computer, tablet, iPad, or smartphone) and internet access at home
* A valid email address

Exclusion Criteria:

* Recurrent or metastatic cancer
* Any other active cancer
* Acute infection
* Acute congestive heart failure
* Acute renal failure
* Cardiac or pulmonary edema
* Sensitive carotid sinus
* Severe carotid blockage
* Uncontrolled hypertension
* Venous thrombosis
* Pregnant people
* Incarcerated patients

About the study

The goal of this study is to evaluate the effectiveness of a standardized lymphedema and fibrosis self-management program (LEF-SMP) to improve LEF self-management and reduce LEF-associated symptom burden, functional deficits, and improve quality of life in head and neck cancer (HNC) survivors.

What is being tested

• Usual Care (behavioral)
• In-Person LEF-SMP (behavioral)
• Telehealth LEF-SMP (behavioral)

Sponsor: Abramson Cancer Center at Penn Medicine · Participants: 204 · Started: Mar 29, 2024

Contact the study team

• Jie Deng, PhD · Phone: 2155732393

Official record on ClinicalTrials.gov — NCT06125743

Locations in the U.S.

Conditions

• Lymphedema
• Head and Neck Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.