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Metastatic Cancer clinical trials in Illinois
52 studies for Metastatic Cancer are looking for participants at sites in Illinois.
Cities in Illinois
- Chicago42 studies
- Arlington Heights7 studies
- Peoria7 studies
- Evanston7 studies
- Joliet6 studies
- Waukegan6 studies
- Cicero5 studies
- Springfield4 studies
- Naperville4 studies
- Champaign3 studies
- North Peoria3 studies
- Galesburg3 studies
- Bloomington3 studies
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
- Advocate Good Shepherd Hospital, Barrington
- Illinois CancerCare-Bloomington, Bloomington
- Illinois CancerCare-Canton, Canton
- and 58 more
RecruitingPhase 2
All ages · All sexes · Updated Nov 12, 2026 · NCT05564377Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene
- Northwestern University, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05372614LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
- Northwest Oncology & Hematology, Barrington
- Elmhurst Hospital Nancy Knowles Cancer Center, Elmhurst
- Edward Cancer Center, Naperville
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06216301Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors
- Northwestern University, Chicago
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT05394103ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
- City of Hope Chicago, Zion
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07007559Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
- Illinois Cancer Specialists, Arlington Heights
- City of Hope, Chicago
- OSF Medical Center, Peoria
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07562152A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
- University of Chicago Medical Center, Chicago
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Nov 6, 2026 · NCT05384626CREO - Microwave Ablation Feasibility Study
- Rush University Medical Center, Chicago
Recruiting
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07817147A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
- City of Hope, Chicago, Chicago
- Northwestern Memorial Hospital, Chicago
- University of Illinois at Chicago, Chicago
- and 3 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07174336A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
- University of Chicago Hospital, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06465069A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
- Illinois Cancer Specialists, Arlington Heights
- Northwestern Memorial Hospital, Chicago
- Rush University Medical Center, Chicago
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07213804A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
- University of Illinois at Chicago, Chicago
- University of Chicago Hospital, Chicago
- Springfield Clinic Main Campus, Springfield
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06119581FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3
- The University of Chicago Medical Center (UCMC), Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT05614739Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 or 2 Systemic Treatment Regimens
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06127407A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
- Northwestern University, Evanston
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT06769698Collection and Storage of Tissue and Blood Samples From Patients With Cancer
- John H Stroger Jr Hospital of Cook County, Chicago
- SSM Health Good Samaritan, Mount Vernon
RecruitingObservational study
2 Months · All sexes · Updated Oct 22, 2026 · NCT02474160REMASTer: REcurrent Brain Metastases After SRS Trial
- University of Chicago, Chicago
Recruiting
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT05124912AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors
- Midwestern Regional Medical Center dba City of Hope Chicago, Zion
RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Oct 20, 2026 · NCT07403721Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)
- Northwestern University, Chicago
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT06311214A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer
- Research Site, Evanston
RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Oct 19, 2026 · NCT07647328A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
- Cancer Care Specialists of Illinois, Decatur
- Decatur Memorial Hospital, Decatur
- Hope and Healing Clinical Research LLC, Hinsdale
- and 2 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT06989437A Clinical Study of MK-8294 in Participants With Advanced Solid Tumors (MK-8294-001)
- Northwestern University ( Site 0101), Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT07030712Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
- Memorial Hospital, Shiloh
- Siteman Cancer Center - Shiloh, Shiloh
- City Of Hope - Chicago, Zion
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07227415Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare - Bloomington, Bloomington
- University of Illinois Hospital and Health Sciences System (Outpatient Cancer Center), Chicago
- and 11 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07222566Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare - Bloomington, Bloomington
- Illinois Cancer Specialists, Chicago
- and 10 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07222800A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
- University of Illinois at Chicago, Chicago
- University of Chicago Medical Center, Chicago
- Endeavor Health, Evanston
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT07218380PRE-ISPY Phase I/II Oncology Platform Program
- The University of Chicago Medicine Comprehensive Cancer Center, Chicago
- UChicago Medicine Comprehensive Cancer Center at Silver Cross Hospital, New Lenox
- UChicago Medicine Orland Park, Orland Park
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
- City of Hope Cancer Center-Chicago, Zion
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07277413A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
- Research Site, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06103864A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)
- University of Chicago, Chicago
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Sep 24, 2026 · NCT05118789Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer
- Northwest Oncology & Hematology, Elk Grove Village
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07028489Study of ISM6331 in Participants With Advanced/Metastatic Mesothelioma or Other Advanced Solid Tumors
- The University of Chicago Medical Center - Duchossois Center for Advanced Medicine, Chicago
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06566079Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
- Northwestern University, Chicago
- Southern Illinois University-Simmons, Springfield
- Carle Foundation Cancer Institute-Urbana, Urbana
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion
- Northwestern University, Chicago
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07594626Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes
- University of Chicago Comprehensive Cancer Center, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05687110Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
- Research Site, Chicago
- Research Site, Peoria
- Research Site, Urbana
RecruitingPhase 3
Ages 18 and older · Women · Updated Jul 29, 2026 · NCT07044336Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors
- The University of Chicago Medicine, Chicago
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Jul 14, 2026 · NCT05533697A Study of PYX-201 in Advanced Solid Tumors
- University of Chicago Medicine, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT05720117(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
- Northwestern University, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jun 16, 2026 · NCT05208047Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors
- Northwestern University, Chicago
- Northwestern Medicine Orland Park, Orland Park
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06630416From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.