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Myelofibrosis clinical trials recruiting in the U.S.

58 studies for Myelofibrosis are recruiting participants at sites across the United States.

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Recently updated studies

Study of INCA036978 in Participants With Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Nov 13, 2026 ยท NCT07441694

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 13, 2026 ยท NCT07357727

A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 10, 2026 ยท NCT06351631

A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 6, 2026 ยท NCT07623161

Study of Momelotinib in Combination With Luspatercept in Participants With Transfusion Dependent Myelofibrosis

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Nov 4, 2026 ยท NCT06517875

A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 29, 2026 ยท NCT07469891

Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

RecruitingObservational study
Ages 18 to 120 ยท All sexes ยท Updated Oct 28, 2026 ยท NCT01137643

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 27, 2026 ยท NCT06661915

A Study to Evaluate DMR-001 in Participants With CALR-mutant Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 27, 2026 ยท NCT07849231

AlloHCT With PegINFa for Myelofibrosis

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 27, 2026 ยท NCT05535764

Selinexor and Pacritinib in JAK Inhibitor-naรฏve MF Patients With Cytopenias

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 27, 2026 ยท NCT07447817

Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Oct 26, 2026 ยท NCT07281781

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 75 ยท All sexes ยท Updated Oct 23, 2026 ยท NCT06059391

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Oct 22, 2026 ยท NCT05320198

Therapeutic RSK1 Targeting in Myeloid Malignancies

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 21, 2026 ยท NCT07379125

Leading in MPNs Beyond Ruxolitinib in Combo With T-Regs

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 21, 2026 ยท NCT05423691

Pacritinib Effectiveness in Real-world Settings

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Oct 21, 2026 ยท NCT07774455

Tolerability of Ropeginterferon Alfa-2b Add-on to Ongoing Ruxolitinib Therapy in Myelofibrosis

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 19, 2026 ยท NCT07521046

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT04176198

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT04282187

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.