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Myelofibrosis clinical trials recruiting in the U.S.

56 studies for Myelofibrosis are recruiting participants at sites across the United States.

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Recently updated studies

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT07357727

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT06661915

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 23, 2026 ยท NCT05320198

A Study of Oral Nuvisertib (TP-3654) in Patients With Myelofibrosis

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 23, 2026 ยท NCT04176198

A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 18, 2026 ยท NCT07469891

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT04282187

High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly

RecruitingPhase 2
Ages 18 to 75 ยท All sexes ยท Updated Sep 16, 2026 ยท NCT06345495

Pacritinib Effectiveness in Real-world Settings

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 14, 2026 ยท NCT07774455

A Telehealth Advance Care Planning Intervention

Recruiting
Ages 60 and older ยท All sexes ยท Updated Sep 11, 2026 ยท NCT05875805

A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib

RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Aug 24, 2026 ยท NCT07623161

TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT

RecruitingPhase 1
Ages 18 to 80 ยท All sexes ยท Updated Aug 17, 2026 ยท NCT07302776

A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT07008118

Quantitative MRI for Myelofibrosis

RecruitingObservational study
Ages 18 to 99 ยท All sexes ยท Updated Jul 31, 2026 ยท NCT01973881

A Study of Ruxolitinib in Combination With Ulixertinib in People With Myelofibrosis

RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Jul 28, 2026 ยท NCT06773195

Study of INCA036978 in Participants With Myeloproliferative Neoplasms

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Jul 22, 2026 ยท NCT07441694

A Study of Rebecsinib for Patients With Relapsed/Refractory Secondary Acute Myeloid Leukemia or High Risk Myelofibrosis

RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Jul 20, 2026 ยท NCT07250646

Reduced Intensity Haploidentical Transplantation for the Treatment of Primary or Secondary Myelofibrosis

RecruitingPhase 2
Ages 18 to 70 ยท All sexes ยท Updated Jul 20, 2026 ยท NCT04370301

Allo HSCT Using RIC and PTCy for Hematological Diseases

RecruitingPhase 2
Up to age 75 ยท All sexes ยท Updated Jul 6, 2026 ยท NCT05805605

Registry of Older Patients With Cancer

RecruitingObservational study
Ages 65 and older ยท All sexes ยท Updated Jun 29, 2026 ยท NCT01137825

Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

RecruitingPhase 2
Up to age 60 ยท All sexes ยท Updated Jun 25, 2026 ยท NCT03314974

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.