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Biofluid Research on Age-Related or Inherited Neurodegeneration
Biofluid Research on Age-Related or Inherited Neurodegeneration (BRAIN)
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: 1. People with a clinical diagnosis of a neurodegenerative disease including, but not limited to Alzheimer's disease (AD), Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), progressive supranuclear palsy (PSP), primary progressive aphasia (PPA), limbic-predominant age-related TDP-43 encephalopathy (LATE), corticobasal syndrome (CBS), posterior cortical atrophy (PCA), primary lateral sclerosis (PLS), primary muscular atrophy (PMA), or individuals with a suspected neurodegenerative dementia and/or movement disorder of unknown etiology will be considered for enrollment 2. Family Members of individuals who meet the criteria of group 1, who are people who may or may not be at risk for a similar neurodegenerative disease, who may or may not be symptomatic, and who may or may not have known or unknown genetic risk. 3. People with no known neurological disease who will provide control data. Exclusion Criteria: 1. Anyone who is under the age of 18. 2. Anyone with a condition or in a situation which, in the investigator's opinion, could confound the study findings or may interfere significantly with a person's participation, including but not limited to neurological, psychological, and other medical conditions (such as cardiac, neurosurgical, infectious conditions).
About the study
The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with age-related neurodegenerative conditions, or their family members who may or may not be at risk for similar conditions. This study will continue to further expand research into the molecular and genetic basis of these diseases and their risk factors.
Sponsor: University of Pennsylvania · Participants: 1,000 · Started: Dec 12, 2025
Contact the study team
- Cara Joyce, MPH · Phone: 267-271-0740
- Emily Xie · Phone: 16109553114
Official record on ClinicalTrials.gov — NCT07798700
Locations in the U.S.
| Pennsylvania | University of Pennsylvania, Philadelphia |
Conditions
- Amyotrophic Lateral Sclerosis
- Primary Progressive Aphasia
- Lewy Body Dementia
- Alzheimer's Disease
- Progressive Supranuclear Palsy
- Parkinson's Disease
- ALS and Motor Neuron Disease
- Dementia
- Nerve Degeneration
- Neuromuscular Disorders
- Movement Disorders
- Degenerative Nerve Diseases
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.