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Sickle Cell Disease clinical trials in California
19 studies for Sickle Cell Disease are looking for participants at sites in California.
Cities in California
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
- University of California San Francisco (UCSF) Medical Center, San Francisco
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07187973A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
- Ctr for Inherited Blood Disorders, Orange
RecruitingPhase 3
Ages 12 to 100 · All sexes · Updated Nov 10, 2026 · NCT06439082HPC Offered for PRESERVE Expansion
- City of Hope, Duarte
RecruitingObservational study
Ages 12 to 80 · All sexes · Updated Nov 6, 2026 · NCT07145411Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
- University of California Irvine, Orange
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07224360Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
- University of California, Davis, Davis
- University of California, Los Angeles, Los Angeles
- UCSF Benioff Children's Hospital, Oakland
RecruitingPhase 1/2
Ages 12 to 35 · All sexes · Updated Oct 20, 2026 · NCT04774536The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
- University of California San Francisco- Site Number : 8400040, Clovis
- David Geffen School of Medicine at UCLA- Site Number : 8400032, Los Angeles
RecruitingPhase 3
Ages 10 to 65 · All sexes · Updated Oct 15, 2026 · NCT06975865Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
- UCLA Mattel Children's Hospital Ronald Reagan Hospital, Los Angeles
Recruiting
Ages 16 to 39 · All sexes · Updated Oct 8, 2026 · NCT06374238Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
- Univ. of California, San Francisco Health Care, Oakland
- University of California Irvine, Orange
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Oct 8, 2026 · NCT06699849Exercise in Child Health
- University of California, Irvine, Irvine
RecruitingHealthy volunteers welcome
Ages 10 to 17 · All sexes · Updated Oct 2, 2026 · NCT05359991A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
- Children's Hospital Los Angeles - Endocrinology, Los Angeles
- UCSF Oakland Benioff ChildHosp, Oakland
RecruitingPhase 3
Ages 2 and older · All sexes · Updated Sep 18, 2026 · NCT06609226A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
- Children's Hospital Los Angeles - Endocrinology, Los Angeles
- Valley Children's Hospital, Madera
- Stanford University_Palo Alto, Palo Alto
- and 1 more
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults
- Harbor UCLA Medical Center, Torrance
RecruitingPhase 2
Ages 5 to 20 · All sexes · Updated Sep 2, 2026 · NCT07369024A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
- University of California San Diego - La Jolla, La Jolla
- UCSF Benioff Children's Hospital Oakland, Oakland
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
- Orthopaedic Institute for Children HTC, Los Angeles
- Childrens Hospital Los Angeles, Los Angeles
- UCSF Benioff Children's Hospital Oakland, Oakland
- and 5 more
RecruitingObservational study
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease
- University of California Los Angeles, Los Angeles
RecruitingPhase 2
6 Months – 21 Years · All sexes · Updated Jul 27, 2026 · NCT02675959Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
- UC Davis Comprehensive Cancer Center, Sacramento
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Jul 16, 2026 · NCT06016634Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
- Children's Hospital Los Angeles, Los Angeles
- Lucile Packard Children's Hospital, Palo Alto
RecruitingPhase 1/2
Ages 12 to 50 · All sexes · Updated Jul 2, 2026 · NCT04819841Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
- UCSF Benioff Children's Hospital Oakland, Oakland
RecruitingPhase 2
Ages 15 to 40 · All sexes · Updated Mar 13, 2026 · NCT06260891Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
- University of California, San Francisco (UCSF), Oakland
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 22, 2025 · NCT06385886From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.