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Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Recruiting

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain: Promoting Engagement in Cognitive Behavioral Therapy

Who can join

Ages 16 to 30 · All sexes

Full eligibility criteria

Inclusion Criteria:

1. Aged 16 to 30 years of age at time of enrollment
2. Sickle Cell Disease diagnosis of any genotype based on referral or documentation
3. Reports chronic pain (≥4 days/week for past 3 months or more) OR A) Being prescribed pain medication to be taken (≥4 days/week for past 3 months or more) OR B) Taking pain medication (≥4 days/week for past 3 months or more) OR C) Receiving non-pharmaceutical pain treatment (≥4 days/week for past 3 months or more)
4. Access to an iOS or Android mobile device with internet access

Exclusion Criteria:

1. Unable to speak or read English
2. Prior hematopoietic stem cell transplant for sickle cell disease

About the study

The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain, opioid use, and healthcare utilization among AYAs with SCD. It also seeks to understand the role of personalized peer support in enhancing engagement and outcomes of digital CBT interventions.

By leveraging existing infrastructure for delivering virtual peer support interventions, tailored digital CBT programs for individuals with SCD, and partnerships with CBOs, the study aims to provide valuable insights into the feasibility and effectiveness of digital CBT as a pain management strategy for this vulnerable population.

What is being tested

CBT+ Health coach (behavioral)
CBT w/o Health Coach ( self-guided) (behavioral)
Usual Care (behavioral)

Sponsor: University of Pittsburgh · Participants: 470 · Started: Mar 10, 2025

Contact the study team

Steffi Siebert, MPH · Phone: 877-649-0176

Official record on ClinicalTrials.gov — NCT06374238

Locations in the U.S.

Alabama	University of South Alabama Medical Center, Mobile
California	UCLA Mattel Children's Hospital Ronald Reagan Hospital, Los Angeles
Connecticut	Connecticut Children's Medical Center, Hartford
Georgia	Children's Healthcare of Atlanta, Atlanta
Illinois	Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago
Michigan	The Regents of the University of Michigan, Ann Arbor
New Jersey	Rutgers New Jersey Medical School, Newark
New York	Weil Cornell Medical College, New York University of Rochester Medical Center, Rochester
North Carolina	Wake Forest Baptist Hospital, Durham East Carolina University Health Medical Center, Greenville
Pennsylvania	UPMC Children's Hospital of Pittsburgh, Pittsburgh UPMC University of Pittsburgh Classical Hematology Adult Clinic, Pittsburgh
Virginia	Virginia Commonwealth University, Richmond

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.