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Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait

Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait

Who can join

Ages 50 and older · Women · Healthy volunteers welcome

Inclusion Criteria:

* Female of African Decent.
* Age 50 years or older.
* Lack of menstrual period for at least 12 consecutive months

Exclusion Criteria:

* Taking medications known to influence bone metabolism (e.g., glucocorticoids, hormonal therapy, cancer or chemotherapy meds, anti-resorptive medications or anabolic therapies).
* Known metabolic bone disorder (e.g., uncontrolled thyroid disease, hyperparathyroidism, Vitamin D deficiency)
* Taking an investigational drug
* Documented sickle cell disease

About the study

This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators estimate enrolling 50 female volunteers who are at least 50 years old and have not had a menstrual period for at least 12 consecutive months. Volunteers need not know whether they have SCT as this will be evaluated as part of the study.

What is being tested

• Healthy volunteers without SCT (other)
• Healthy volunteers with SCT (other)

Sponsor: UConn Health · Participants: 50 · Started: Aug 23, 2022

Contact the study team

• Zoe Green, BS · Phone: 860.679.4656

Official record on ClinicalTrials.gov — NCT07083531

Locations in the U.S.

Conditions

• Sickle Cell Disease
• Sickle Cell Trait

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.