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Heart Failure clinical trials in North Carolina
42 studies for Heart Failure are looking for participants at sites in North Carolina.
Cities in North Carolina
- Durham26 studies
- Charlotte11 studies
- Asheville7 studies
- Raleigh7 studies
- Greenville6 studies
- Wilmington6 studies
- Greensboro6 studies
- Winston-Salem5 studies
- Statesville4 studies
- Cary3 studies
ELEVATE-HFpEF Clinical Study
- Duke University Medical Center, Durham
Recruiting
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
- Research Site, Asheville
- Research Site, Chapel Hill
- Research Site, Charlotte
- and 3 more
RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Oct 2, 2026 · NCT06307652A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
- IMA Clinical Research Lenoir, Lenoir
- Pinehurst Medical Clinic, Inc. - East, Pinehurst
- Piedmont Healthcare, Inc., Statesville
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06935370A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
- Medication Management, LLC, Greensboro
- WakeMed, Raleigh
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06424288A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
- Duke University, Durham
RecruitingPhase 2
Ages 40 to 84 · All sexes · Updated Sep 30, 2026 · NCT06979362Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
- Wake Forest University, Winston-Salem
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT06517186HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
- Wake Forest University, Winston-Salem
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT05873634A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
- Research Site, Chapel Hill
- Research Site, Durham
- Research Site, Greensboro
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117BiVACOR® Total Artificial Heart Early Feasibility Study
- Duke University Hospital, Durham
Recruiting
Ages 18 to 70 · All sexes · Updated Sep 28, 2026 · NCT06174103Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
- WakeMed Heart & Vascular - Cary Cardiology, Cary
- Clinical and Translational Research Center - University of North Carolina at Chapel Hill, Chapel Hill
- Duke University Hospital, Durham
- and 2 more
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574A Study of LY3971297 in Participants With Heart Failure
- University of North Carolina, Division of Cardiology, Chapel Hill
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT07547540Alleviant ALLAY-HFrEF Study
- Mission Hospital, Asheville
- Duke University Hospital, Durham
- NC Heart and Vascular Research, Raleigh
Recruiting
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
- Asheville Cardiology Associates, Asheville
- Duke University Health System, Durham
- Ima Clinical Research - Lenoir, Lenoir
- and 2 more
RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
- Research Site, Charlotte
- Research Site, Durham
- Research Site, Fayetteville
- and 6 more
RecruitingPhase 3
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
- CON-10318, Charlotte, NC, Charlotte
- Greenville, NC Investigative Site CON-10122, Greenville
- Morrisville, NC Investigative Site CON-10317, Morrisville
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06024746A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
- Greenville, NC Investigative Site 10122, Greenville
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
- Duke University, Durham
Recruiting
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
- Sanger Heart and Vascular Institute, Charlotte
- Duke University Medical Center, Durham
Recruiting
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07069738A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
- Local Institution - 159, Greensboro
RecruitingPhase 2
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
- Atrium Health Sanger Heart and Vascular Institute, Charlotte
Recruiting
Ages 21 and older · All sexes · Updated Aug 25, 2026 · NCT05677100Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
- Duke University Health System, Durham
RecruitingObservational studyHealthy volunteers welcome
Ages 0 to 20 · All sexes · Updated Aug 21, 2026 · NCT04278404Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
- Durham
- Raleigh
RecruitingObservational study
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
- Focus Clinical Research, Charlotte
- Duke University Health System, Durham
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05489705LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
- Tenax Investigational Site, Durham
- Tenax Investigational Site, Winston-Salem
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
- Peak Clinical Trials, Apex
- Hawthorne Health NC, Concord
- Duke University, Durham
- and 5 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001Alleviant ALLAY-HF Study
- Mission Hospital, Asheville
- Duke University Hospital, Durham
- NC Heart and Vascular Research, Raleigh
Recruiting
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
- Duke University Hospital, Durham
RecruitingPhase 2
Ages 0 to 16 · All sexes · Updated Aug 10, 2026 · NCT06080074CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study
- Sanger Heart and Vascular Institute, Charlotte
Recruiting
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT06096675A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
- FIN-10318, Charlotte, NC, Charlotte
- Greenville, NC Investigative Site FIN-10122, Greenville
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06033950PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
- UNC Medical Center, Durham
- Duke University, Durham
Recruiting
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
- University of North Carolina at Chapel Hill, Chapel Hill
- Carolinas Medical Center, Charlotte
Recruiting
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
- Moses H. Cone Memorial Hospital, Greensboro
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT06699056BOOST: Blended Onsite and Offsite Structured Exercise Training and Coaching
- Wake Forest University Health Sciences, Winston-Salem
Recruiting
Ages 55 and older · All sexes · Updated May 26, 2026 · NCT07413198Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection Fraction
- Duke, Durham
Recruiting
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06733012Developing a Digital Aid to Improve ICD Decisions
- Eastern Carolina University, Greenville
Recruiting
Ages 60 and older · All sexes · Updated Apr 27, 2026 · NCT07084142The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study
- UNC Eastowne Kidney Transplant Clinic, Chapel Hill
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT06059664XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)
- Duke University Medical Center, Durham
Recruiting
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06895070His-Bundle Corrective Pacing in Heart Failure
- Mission Health, Asheville
Recruiting
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT05265520Supporting Health in Veterans With Heart Failure
- VA Clinic - Durham, Durham
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 13, 2025 · NCT05839067Left vs Left Randomized Clinical Trial
- MH Mission Hospital LLLP- Asheville Cardiology Associates, Asheville
- University of North Carolina, Chapel Hill
- Novant Health, Charlotte
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2025 · NCT05650658From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.