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Metastatic Cancer clinical trials in Oklahoma City, OK

16 studies for Metastatic Cancer are looking for participants at sites in and around Oklahoma City (within about 30 miles). Open a study to see who can join and how to contact the study team.

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BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

RecruitingPhase 1/2
  • Avenzo Therapeutics Recruiting Site, Oklahoma City
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07193511

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • University of Oklahoma Health Sciences Center, Oklahoma City
All ages · All sexes · Updated Oct 5, 2026 · NCT05564377

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Oklahoma, Oklahoma City
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

RecruitingPhase 1
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05803382

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • University of Oklahoma Health Sciences Center, Stephenson Cancer Center, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • University of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

RecruitingPhase 2
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06311214

FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

RecruitingPhase 1
  • University of Oklahoma - Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05614739

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

RecruitingPhase 1
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT05687110

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

RecruitingPhase 1/2
  • University of Oklahoma Health Sciences Center, Oklahoma City
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT05691491

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Stephenson Cancer Center, Oklahoma City
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

RecruitingPhase 1/2
  • Sarah Cannon Research Institute University of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated May 19, 2026 · NCT05431270

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

RecruitingObservational study
  • Mercy Hospital Oklahoma City, Oklahoma City
2 Months · All sexes · Updated Mar 5, 2026 · NCT02474160

Circulating Tumor DNA Response In Urothelial Cancer

RecruitingPhase 2
  • OU Health Stephenson Cancer Center, Oklahoma City
Ages 18 and older · All sexes · Updated Feb 2, 2026 · NCT07183319

Spine Radiosurgery for Symptomatic Metastatic Neoplasms

RecruitingPhase 2
  • OU Health Stephenson Cancer Center, Oklahoma City
Ages 18 and older · All sexes · Updated Oct 20, 2025 · NCT05617716

A Study of NX-1607 in Adults With Advanced Malignancies

RecruitingPhase 1
  • University of Oklahoma, Oklahoma City
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT05107674

Metastatic Cancer trials in other cities

Other studies in Oklahoma City

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.