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Non-Small Cell Lung Cancer clinical trials in Winston-Salem, NC

12 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Winston-Salem (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Wake Forest University Health Sciences, Winston-Salem
  • Wake Forest University at Clemmons, Clemmons · 9 mi away
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT04267848

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

RecruitingPhase 3
  • Novant Health Forsyth Medical Center ( Site 0166), Winston-Salem
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06623422

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

RecruitingPhase 3
  • Novant Health Pharmacy Oncology Specialists, Winston-Salem
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07361497

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

RecruitingPhase 3
  • Novant Health Pharmacy Oncology Specialists, Winston-Salem
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07361510

Pilot Study of Performance Status 2 vs. Performance Status 0-1 Non-small Cell Lung Cancer Patients Treated With Chemo/Immunotherapy

RecruitingPhase 2
  • Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04253964

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06667076

Quick Start Durvalumab Following Chemoradiation for Stage III Nonsmall Cell Lung Cancer

RecruitingPhase 2
  • Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT05696782

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

RecruitingPhase 3
  • Atrium Health Wake Forest Baptist, Winston-Salem
Ages 18 to 100 · All sexes · Updated Aug 19, 2026 · NCT05317858

Cancer-related Fatigue During Maintenance Immunotherapy for Non-small Cell Lung Cancer (NSCLC): a Qualitative Study

RecruitingObservational study
  • Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06567704

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

RecruitingPhase 2
  • Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem
Ages 18 and older · All sexes · Updated Jul 17, 2026 · NCT05692635

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Wake Forest NCORP Research Base, Winston-Salem
  • Wake Forest University Health Sciences, Winston-Salem
  • Wake Forest University at Clemmons, Clemmons · 9 mi away
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Winston-Salem
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Non-Small Cell Lung Cancer trials in other cities

Other studies in Winston-Salem

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.