Home › Non-Small Cell Lung Cancer › Texas › San Antonio

Non-Small Cell Lung Cancer clinical trials in San Antonio, TX

60 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around San Antonio (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors

RecruitingPhase 1/2

START San Antonio (STSA), San Antonio

Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07488676

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy With or Without Amivantamab for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

RecruitingPhase 2/3

Local Institution - 0173, San Antonio

Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07100080

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1

UT Health San Antonio's Mays Cancer Center, San Antonio

Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06270706

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

RecruitingPhase 1/2

START | San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06914128

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

RecruitingPhase 1

NEXT Texas LLC - San Antonio, San Antonio
START San Antonio, LLC, San Antonio

Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07503808

Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib Versus Osimertinib Monotherapy or Osimertinib in Combination With Platinum-based Chemotherapy for EGFRmt Non-small Cell Lung Cancer (IZABRIGHT-Lung02)

RecruitingPhase 3

Texas Oncology - San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07680790

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

RecruitingPhase 3

Jason Bates at University of Texas Health Science Center, San Antonio

Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT06216301

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07090499

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

RecruitingPhase 3

Texas Oncology - San Antonio Medical Center, San Antonio

Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07361497

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1

South Texas Accelerated Research Therapeutics (START), San Antonio

Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06465069

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

RecruitingPhase 3

USO - Texas Oncology - San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06890598

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

RecruitingPhase 1/2

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07397338

A Study to Investigate the Safety and Efficacy of KQB368 as Monotherapy in Participants With Advanced Solid Malignancies

RecruitingPhase 1

START San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07542704

A Study to Learn About the Study Medicine Called PF-08098488 in People With Advanced Solid Tumors.

RecruitingPhase 1

START San Antonio, LLC, San Antonio

Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07903415

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

RecruitingPhase 1

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT06720987

M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors

RecruitingPhase 1

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07166601

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

RecruitingPhase 1

UT Health San Antonio - MD Anderson Cancer Center, San Antonio

Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06774963

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

RecruitingPhase 3

Texas Oncology - San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06875310

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1

Research Site #2, San Antonio
Research Site, San Antonio

Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06835569

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

RecruitingPhase 3

Texas Oncology - San Antonio, San Antonio
Local Institution - 0381, San Antonio

Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT07361510

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT07705334

Study of PF-07248144 in Advanced or Metastatic Solid Tumors

RecruitingPhase 2

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT04606446

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

RecruitingPhase 1/2

South Texas Accelerated Research Therapeutics, LLC, San Antonio
UT Health San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT06244771

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT06239194

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

RecruitingPhase 1

Site 102 - START San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT07462377

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2

START San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT05786924

A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors

RecruitingPhase 1/2

Clinical Trial Site, San Antonio

Ages 18 and older · All sexes · Updated Oct 13, 2026 · NCT07749586

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

RecruitingPhase 1/2

South Texas Accelerated Research Therapeutics (START), LLC, San Antonio

Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT07070232

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2

Research Site, San Antonio

Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07115043

A Study of ZW251 in Participants With Advanced Solid Tumors

RecruitingPhase 1

START San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07164313

Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

RecruitingPhase 1

START - San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06784193

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2

New Experimental Therapeutics of San Antonio - NEXT Oncology, San Antonio

Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1

University of Texas San Antonio (UTSA), San Antonio

Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

A Study of PHN-012 in Patients With Advanced Solid Tumors

RecruitingPhase 1

PHN-012-001 Site, San Antonio

Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07127874

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2

NEXT Oncology San Antonio, San Antonio
START Texas, San Antonio

Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

RecruitingPhase 1/2

START South Texas Accelerated Research Therapeutics, San Antonio

Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

RecruitingPhase 1

NEXT, San Antonio
START - San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07349537

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

RecruitingObservational study

The University of Texas Health Science Center at San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

RecruitingPhase 1

South Texas Accelerated Research Therapeutics, San Antonio

Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05245500

Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2

START San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Aug 13, 2026 · NCT05985655

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2

UT Health Mays Cancer Center, San Antonio

Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

RecruitingPhase 1

START - San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07444814

AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

RecruitingPhase 1

Next Oncology, San Antonio

Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT07094113

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

RecruitingPhase 1

South Texas Accelerated Research Therapeutics, LLC, San Antonio

Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT06131840

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

RecruitingPhase 1

NEXT Virginia, LLC, San Antonio
South Texas Accelerated Research Therapeutics, LLC, San Antonio

Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

RecruitingPhase 1

New Experimental Therapeutics of San Antonio LLC, San Antonio
START - South Texas Accelerated Research Therapeutics, LLC, San Antonio

Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT07300150

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

RecruitingPhase 1

NEXT Oncology /ID# 243007, San Antonio
South Texas Accelerated Research Therapeutics (START) /ID# 276268, San Antonio

Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT05005403

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1

Research Site, San Antonio

Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT07284186

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1

START, San Antonio

Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated May 28, 2026 · NCT07223047

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2

Next Oncology, San Antonio

Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation

RecruitingPhase 1/2

NEXT Oncology, San Antonio

Ages 18 to 75 · All sexes · Updated Apr 24, 2026 · NCT06385925

This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

RecruitingPhase 1

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Apr 2, 2026 · NCT06451497

A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors

RecruitingPhase 1/2

Research Site, San Antonio

Ages 18 and older · All sexes · Updated Mar 2, 2026 · NCT06956690

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2

START San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors

RecruitingPhase 1/2

START San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT07145255

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

RecruitingPhase 1/2

Next Oncology, San Antonio, San Antonio

Ages 18 and older · All sexes · Updated Jan 29, 2026 · NCT07148128

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

RecruitingPhase 1

Dren Investigational Site, San Antonio

Ages 18 and older · All sexes · Updated Jan 7, 2026 · NCT06999187

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

RecruitingPhase 1/2

NEXT Oncology, San Antonio

Ages 18 and older · All sexes · Updated Jan 7, 2025 · NCT06090266

Non-Small Cell Lung Cancer trials in other cities

Other studies in San Antonio

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.