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Non-Small Cell Lung Cancer clinical trials in Houston, TX

145 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

RecruitingPhase 3
  • Houston Methodist Cancer Center ( Site 0191), Houston
  • MD Anderson Cancer Center ( Site 0150), Houston
  • Memorial Hermann Cancer Center ( Site 0172), Houston
  • and 2 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06623422

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

RecruitingPhase 3
  • Texas Oncology - Gulf Coast, Houston
  • The University of Texas MD Anderson Cancer Center Diagnostic Imaging, Houston
  • The University of Texas MD Anderson Cancer Center, Houston
  • and 5 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07144280

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Houston Methodist Hospital, Houston
  • Houston Methodist West Hospital, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04267848

A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07154290

Dyadic Yoga Program for Patients Undergoing Thoracic Radiotherapy and Their Family Caregivers: The Testing of a Mobile Application Delivery

Recruiting
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06919874

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

RecruitingPhase 3
  • Oncology Consultants PA, Houston
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 to 100 · All sexes · Updated Sep 25, 2026 · NCT05920356

Ph1/2 Trial Of Navlimetostat With Pumitamig In MTAP-Deficient Advanced Non-Small Cell Lung Cancer

RecruitingPhase 1/2
  • UT MD Anderson, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07579221

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Kelsey Research Foundation, Houston
  • Kelsey-Seybold Clinic - North Houston Campus, Houston
  • Texas Oncology - Gulf Coast, Houston
  • and 5 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06667908

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

RecruitingPhase 3
  • The University of Texas MD Anderson Cancer Center Diagnostic Imaging, Houston
  • The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services, Houston
  • The University of Texas, MD Anderson Cancer Center- Interventional Radiology, Houston
  • and 3 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06758401

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

RecruitingPhase 1
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06218914

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07659782

Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

RecruitingPhase 1/2
  • Southwest Oncology Associates, Houston
  • Lumi Research, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07227298

Pan-tumor MRD Study

RecruitingObservational study
  • Onocology Consultants P.A. (Oncology Consultants [OC Houston]), Houston
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Kelsey-Seybold Clinic, Houston
  • Houston Methodist Hospital, Houston
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06890598

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

RecruitingPhase 3
  • University of Texas MD Anderson Cancer Center, Houston
  • Local Institution - 0517, Houston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06561386

Intratumoral N17350 in Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

RecruitingPhase 2
  • Research Site, Houston
Ages 18 to 95 · All sexes · Updated Sep 23, 2026 · NCT05061550

An External Control Arm Study in Non-Small Cell Lung Cancer

RecruitingObservational study
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174388

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

RecruitingPhase 2/3
  • Local Institution - 0025, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07100080

Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer

RecruitingObservational study
  • Oncology Consultants, P.A., Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07028489

A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors

RecruitingPhase 1/2
  • Next Oncology - Houston, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07488676

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • MD Anderson, Houston
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07629960

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, P.A., Houston
  • University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

RecruitingPhase 3
  • Clinical Study Site, Houston
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06767514

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07705334

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07020117

Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

RecruitingPhase 3
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07195695

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

RecruitingPhase 3
  • University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06899126

TT-4 and TT-10 as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors and Pleural Mesothelioma

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04969315

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT04585750

Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

RecruitingPhase 2
  • MD ANDERSON CANCER CENTER (Data Collection Only), Houston
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04410796

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT04302025

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07462377

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06625775

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • MD Anderson Cancer Center - University of Texas, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

RecruitingPhase 3
  • The University of Texas-MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07361497

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

RecruitingPhase 3
  • Kelsey-Seybold Clinic Main Campus, Houston
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07361510

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Houston Methodist Hospital, Houston
  • University of Texas MD Anderson Cancer Center, Houston
  • Lumi Research, Houston
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06561685

A Study of Sofe-M in Participants With Selected Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas - MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06400472

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06465069

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
  • The University of Texas, MD Anderson Cancer Center - West Houston, Houston
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07090499

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

RecruitingPhase 1
  • Oncology Consultants Texas Medical Center, Houston
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06343402

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

RecruitingPhase 3
  • Memorial Hermann Cancer Center ( Site 0015), Houston
  • Oncology Consultants P.A. ( Site 0124), Houston
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06422143

Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs

RecruitingPhase 1/2
  • Oncology Consultants (OC) - Texas Medical Center - Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06567015

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07216105

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

RecruitingPhase 1
  • MD Anderson, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

RecruitingPhase 1/2
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06043817

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

RecruitingPhase 1
  • MDACC, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05245500

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Houston
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT05877599

A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 to 99 · All sexes · Updated Sep 1, 2026 · NCT06983743

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

RecruitingPhase 3
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06881784

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

RecruitingPhase 3
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT06350097

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT06892548

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

RecruitingObservational study
  • The University of Texas MD Anderson Cancer Center ( Site 0009), Houston
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT04165798

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06586515

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

RecruitingPhase 1
  • MD Anderson, Houston
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT06774963

A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung Cancer

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07133425

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07115043

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Houston Methodist Hospital, Houston
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04895709

SMP-3124LP in Adults With Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06526819

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas, MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

A Study of MGC026 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
  • University of Texas Health Science Center at Houston, Houston
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06242470

Phase 1 Study Of Izalontamab Brengitecan + Adagrasib In NSCLC - The IZA-A Trial

RecruitingPhase 1
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT07382726

Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cell Lung Cancer

RecruitingObservational study
  • M D Anderson Cancer Center, Houston
All ages · All sexes · Updated Aug 11, 2026 · NCT04913311

A Study of PHN-012 in Patients With Advanced Solid Tumors

RecruitingPhase 1
  • PHN-012-001 Site, Houston
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07127874

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

RecruitingPhase 1/2
  • University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07111520

Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • NEXT - Oncology - Houston, Houston
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT07444814

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

RecruitingPhase 1/2
  • The University of Texas - M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06706076

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
  • NEXT Houston, Houston
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT06270706

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 3, 2026 · NCT07397338

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

RecruitingPhase 1
  • Uni Of TX MD Anderson Cancer Cntr, Houston
Ages 18 to 100 · All sexes · Updated Jul 29, 2026 · NCT06562192

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

RecruitingPhase 1
  • Md Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT06179160

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT06131840

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services, Houston
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05142189

Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

RecruitingPhase 1/2
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT05098132

A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

RecruitingPhase 1
  • Local Institution - 0049, Houston
Ages 18 and older · All sexes · Updated Jul 20, 2026 · NCT06476808

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

RecruitingPhase 1/2
  • M.D. Anderson Cancer Center (Melanoma/NSCLC), Houston
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06060613

Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer

RecruitingPhase 1
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT03819296

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

RecruitingPhase 2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06695845

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
  • NEXT Oncology Houston, Houston
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT05873686

Study of NXP900 With Osimertinib in Subjects With Advanced, EGFR-Mutated Non-Small Cell Lung Cancer

RecruitingPhase 1
  • NEXT Houston, Houston
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT07315113

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, PA, Houston
  • Oncology Consultants, PA., Houston
  • The University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Jul 1, 2026 · NCT07098338

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT06162221

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

RecruitingPhase 3
  • Houston Methodist Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06216301

A Study of LY4175408 in Participants With Advanced Cancer

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT07046923

Study of XB010 in Subjects With Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06545331

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

RecruitingPhase 1
  • MD Anderson, Houston
  • NEXT Texas LLC - Houston, Houston
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT07503808

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors

RecruitingPhase 1
  • NEXT Texas LLC - Houston, Houston
Ages 18 to 99 · All sexes · Updated Jun 16, 2026 · NCT07540572

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT06789172

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06026410

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center /ID# 252004, Houston
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04777994

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • University of Texas, MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer

RecruitingPhase 1
  • Houston Methodist Neal Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 28, 2026 · NCT06566443

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

RecruitingPhase 2
  • USA12-0, Houston
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06953089

Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)

RecruitingPhase 3
  • MD Anderson, Houston
Ages 18 and older · All sexes · Updated May 19, 2026 · NCT07154706

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 19, 2026 · NCT05431270

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

RecruitingPhase 1
  • ALX Center 5, Houston
Ages 18 and older · All sexes · Updated May 12, 2026 · NCT07085091

A Study of ZW251 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 7, 2026 · NCT07164313

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06239194

A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 to 75 · All sexes · Updated Apr 24, 2026 · NCT06385925

A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC

RecruitingPhase 2
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 24, 2026 · NCT06010329

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07020221

Study of PF-07248144 in Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • The University of Texas M. D. Anderson Cancer Center, Houston
  • U.T. MD Anderson Cancer Center, Houston
  • MD Anderson West Houston, Houston
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT04606446

Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non-small Cell Lung or Esophageal Cancer Undergoing Radiotherapy and Their Caregivers

RecruitingHealthy volunteers welcome
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT03948100

Couple-Based Meditation for Metastatic Lung Cancer Patients and Their Partners

RecruitingHealthy volunteers welcome
  • Memorial Hermann, Houston
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT02596490

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

RecruitingPhase 1
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT04686305

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06362369

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06810544

A Study of VET3-TGI in Patients With Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 7, 2026 · NCT06444815

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Mar 18, 2026 · NCT06244771

Repositioning Immunotherapy in VetArans With Lung Cancer

RecruitingPhase 2
  • Michael E. DeBakey VA Medical Center, Houston, TX, Houston
Ages 18 and older · All sexes · Updated Mar 2, 2026 · NCT06275360

Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

Recruiting
  • Michael E. DeBakey VA Medical Center, Houston, TX, Houston
Ages 18 and older · All sexes · Updated Feb 19, 2026 · NCT02984761

EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer

RecruitingPhase 1/2
  • Michael E. DeBakey VA Medical Center, Houston, TX, Houston
Ages 18 and older · All sexes · Updated Jan 27, 2026 · NCT05467748

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Jan 12, 2026 · NCT07181473

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center (site 127), Houston
Ages 18 to 80 · All sexes · Updated Dec 11, 2025 · NCT03556228

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT06943521

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Houston
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Study of NX-1607 in Adults With Advanced Malignancies

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT05107674

A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • MD Anderson Cancer Hospital, Houston
Ages 18 and older · All sexes · Updated Aug 17, 2025 · NCT06907615

BostonGene and Exigent Genomic INsight Study

RecruitingObservational study
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Feb 17, 2025 · NCT06272864

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

RecruitingPhase 1/2
  • Oncology Consultants, P.A., Houston
  • The University of Texas M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Feb 13, 2025 · NCT05669430

A Study of IBI363 in Subjects with Advanced Solid Malignancies

RecruitingPhase 2
  • MD Anderson Cancer Center-University of Texas, Houston
  • Oncology Consultants P.A., Houston
Ages 18 and older · All sexes · Updated Dec 19, 2024 · NCT06281678

Non-Small Cell Lung Cancer trials in other cities

Other studies in Houston

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.