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Esophageal Cancer clinical trials in New York City, NY

22 studies for Esophageal Cancer are looking for participants at sites in and around New York City (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • NYU Langone Medical Center - Perlmutter Cancer Center (NYU Cancer Institute), New York
  • NYU Langone Medical Center - Perlmutter Cancer Center (NYU Cancer Institute), New York
  • Icahn School of Medicine at Mount Sinai, New York
  • and 2 more
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Memorial Sloan Kettering Hospital, New York
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

RecruitingPhase 2
  • Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06123338

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

RecruitingPhase 1
  • New York University (NYU) Langone Medical Center, New York
  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • New York University (NYU) Clinical Cancer Center, New York
  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • Columbia University, New York
  • NYU Langone Health, New York
  • Memorial Sloan Kettering Cancer Center, New York
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Memorial Sloan Kettering Cancer Center Head Neck Services, New York
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

RecruitingPhase 3
  • Icahn School of Medicine at Mount Sinai, New York
  • Memorial Sloan Kettering Cancer Center, New York
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07217704

A Study of 2141-V11 in People With Esophageal, Gastric, or Gastroesophageal Junction Adenocarcinoma

RecruitingPhase 1/2
  • Memorial Sloan Kettering Cancer Center (All Protocol Activites), New York
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07818018

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

RecruitingPhase 1
  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06293898

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

RecruitingPhase 3
  • Research Site, New York
  • Research Site, New York
  • Research Site, New York
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07431281

Retrospective Review of Esophageal Cancer at MSKCC

RecruitingObservational study
  • Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT05706558

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

RecruitingPhase 1
  • Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07227168

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

RecruitingObservational studyHealthy volunteers welcome
  • Columbia University Medical Center, New York
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT00288119

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Mt. Sinai, New York
  • Memorial Sloan Kettering Cancer Center, New York
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

RecruitingPhase 2
  • Memorial Sloan Kettering Cancer Center, New York
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06695845

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists, New York
  • Columbia University Irving Medical Center, New York
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

Registry for Esophageal and Gastroesophageal Junction Cancer

RecruitingObservational study
  • Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06558786

Brodalumab in the Treatment of Immune-Related Adverse Events

RecruitingPhase 1
  • Columbia University Irving Medical Center, New York
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT06673329

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

RecruitingPhase 1/2
  • Weill Cornell Medicine, Cornell University (site 126), New York
Ages 18 to 80 · All sexes · Updated Dec 11, 2025 · NCT03556228

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, New York
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Esophageal Cancer

Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.

More about Esophageal Cancer on MedlinePlus

Esophageal Cancer trials in other cities

Other studies in New York City

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.