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A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
- Augusta University Georgia, Augusta
- WCG Sonar Clinical Research, Riverdale
Renkami dalyviai3 fazė
Amžius nuo 12 iki 100 · Visoms lytims · Atnaujinta 2026-09-28 · NCT06439082A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
- Emory University, Atlanta
- Augusta University, Augusta
Renkami dalyviai1 fazė
Amžius 18 ir vyresni · Visoms lytims · Atnaujinta 2026-09-23 · NCT07187973A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
- Children's Healthcare Atlanta, Atlanta
Renkami dalyviai3 fazė
Amžius 2 ir vyresni · Visoms lytims · Atnaujinta 2026-09-18 · NCT06609226A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
- Children's Healthcare Atlanta, Atlanta
Renkami dalyviai3 fazė
Amžius 12 ir vyresni · Visoms lytims · Atnaujinta 2026-09-17 · NCT06612268Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
- Children's Healthcare of Atlanta, Atlanta
Renkami dalyviai
Amžius nuo 8 iki 18 · Visoms lytims · Atnaujinta 2026-09-10 · NCT07562451A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
- Winship Cancer Institute of Emory University, Atlanta
Renkami dalyviai1/2 fazėLaukiami sveiki savanoriai
Amžius 18 ir vyresni · Visoms lytims · Atnaujinta 2026-08-18 · NCT06481306A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
- Children's Center for Advanced Pediatrics, Atlanta
Renkami dalyviai2/3 fazė
Amžius 12 ir vyresni · Visoms lytims · Atnaujinta 2026-08-18 · NCT05431088ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
- Comprehensive Bleeding Disorders Center at Emory University and Children's Healthcare of Atlanta, Atlanta
- Emory/Children's Health Care of Atlanta, Atlanta
- Memorial Health University Medical Center, Savannah
Renkami dalyviaiStebimasis tyrimas
Visi amžiai · Visoms lytims · Atnaujinta 2026-08-17 · NCT04398628Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
- Arthur M. Blank Hospital-Children's Healthcare of Atlanta, Atlanta
Renkami dalyviai2 fazė
Amžius 12 ir vyresni · Visoms lytims · Atnaujinta 2026-08-14 · NCT06699849Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
- Arthur M. Blank Hospital- Children's Healthcare of Atlanta, Atlanta
Renkami dalyviai2 fazė
Amžius 18 ir vyresni · Visoms lytims · Atnaujinta 2026-08-05 · NCT07224360Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease
- Children's Healthcare fo Atlanta at Hughes Spalding, Atlanta
- Children's Healthcare of Atlanta at Arthur M. Blank Hospital, Atlanta
Renkami dalyviai1/2 fazė
Amžius nuo 7 iki 21 · Visoms lytims · Atnaujinta 2026-07-29 · NCT02447874Cooperative Assessment of Late Effects for SCD Curative Therapies
- Emory University School of Medicine, Atlanta
Renkami dalyviaiStebimasis tyrimas
Amžius nuo 4 iki 65 · Visoms lytims · Atnaujinta 2026-07-27 · NCT05153967Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
- Augusta University Georgia, Augusta
Renkami dalyviai4 fazė
6 Months – 100 Years · Visoms lytims · Atnaujinta 2026-06-08 · NCT04657822Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
- Children's Healthcare of Atlanta, Atlanta
Renkami dalyviai1/2 fazė
Amžius nuo 12 iki 45 · Visoms lytims · Atnaujinta 2026-06-04 · NCT07252050Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
- Children's Healthcare of Atlanta (MRD-HCT), Atlanta
Renkami dalyviaiStebimasis tyrimas
Amžius nuo 3 iki 20 · Visoms lytims · Atnaujinta 2026-06-04 · NCT06941389Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
- Emory University, Atlanta
Renkami dalyviai4 fazė
Amžius nuo 18 iki 50 · Moterims · Atnaujinta 2026-05-28 · NCT06665997A Socio-ecological Approach for Improving Self-management in Adolescents With SCD
- Children's Healthcare of Atlanta, Atlanta
Renkami dalyviai
Amžius nuo 13 iki 21 · Visoms lytims · Atnaujinta 2026-05-11 · NCT06290401Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease
- Site # 8400006, Atlanta
- Site # 8400002, Atlanta
Renkami dalyviai3 fazė
Amžius nuo 2 iki 17 · Visoms lytims · Atnaujinta 2026-04-15 · NCT07247188Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease
- Grady Health System, Atlanta
Renkami dalyviai4 fazėLaukiami sveiki savanoriai
Amžius 18 ir vyresni · Moterims · Atnaujinta 2026-02-18 · NCT06979492A Long-term Follow-up Study in Patients Who Received BEAM-101
- Children's Healthcare of Atlanta - Aflac Cancer and Blood Disorders Center- Egleston, Atlanta
Renkami dalyviaiStebimasis tyrimas
Amžius nuo 14 iki 37 · Visoms lytims · Atnaujinta 2026-01-28 · NCT07373639Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease
- Children's Hospital of Atlanta: Eagelston, Atlanta
Renkami dalyviai
Amžius nuo 7 iki 18 · Visoms lytims · Atnaujinta 2026-01-26 · NCT07090668Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease
- Augusta University, Augusta
Renkami dalyviai1 fazė
Amžius 18 ir vyresni · Visoms lytims · Atnaujinta 2026-01-09 · NCT01245179Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
- Children's Healthcare of Atlanta, Atlanta
Renkami dalyviai
Amžius nuo 16 iki 30 · Visoms lytims · Atnaujinta 2026-01-07 · NCT06374238Integrative Training Program for Pediatric Sickle Cell Pain
- Children's Healthcare of Atlanta, Atlanta
- Arthur M. Blank Hospital | Children's Healthcare of Atlanta, Atlanta
Renkami dalyviai
Amžius nuo 12 iki 18 · Visoms lytims · Atnaujinta 2025-11-14 · NCT06691867Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
- Augusta University, Augusta
Renkami dalyviaiStebimasis tyrimas
Amžius 18 ir vyresni · Visoms lytims · Atnaujinta 2025-06-22 · NCT06385886Iš ClinicalTrials.gov, duomenys gauti 2026-10-05. Kiekvienas tyrimas nustato savo tinkamumo kriterijus; tyrimo komanda sprendžia, kas gali dalyvauti.