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Breast Cancer clinical trials in Springfield, MO

10 studies for Breast Cancer are looking for participants at sites in and around Springfield (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mercy Hospital Springfield, Springfield
  • CoxHealth South Hospital, Springfield
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

RecruitingPhase 2
  • Oncology Hematology Associates, Springfield
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06369285

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Oncology Hematology Associates, Springfield
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

RecruitingObservational study
  • Oncology Hematology Associates, Springfield
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07211178

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

RecruitingPhase 3
  • Mercy Hospital Springfield, Springfield
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06500481

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Mercy Hospital Springfield, Springfield
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Mercy Hospital Springfield, Springfield
  • CoxHealth South Hospital, Springfield
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Mercy Hospital Springfield, Springfield
  • Cox Health South Hospital, Springfield
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • Mercy Hospital Springfield, Springfield
  • CoxHealth South Hospital, Springfield
Ages 18 and older · All sexes · Updated Oct 8, 2025 · NCT03418961

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Springfield

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.