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Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study

Genetic Epidemiology of Severe, Early-Onset Chronic Obstructive Pulmonary Disease

Who can join

All ages · All sexes

Inclusion Criteria for Early-Onset COPD Probands:

* Early onset of COPD in individuals younger than 53 years old
* Spirometry results that are indicative of severe COPD (FEV1 \< 40% predicted)
* Physician-diagnosed COPD

Exclusion Criteria for Early-Onset COPD Probands:

* Severe alpha-1 antitrypsin deficiency
* Other chronic lung diseases in participants with COPD (except asthma)
* Pregnant
* Any previous lung surgery including lung transplant or lung reduction volume surgery (LVRS); unless prior Pulmonary Function Tests are available

About the study

Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that predispose some individuals to develop COPD.

Sponsor: Brigham and Women's Hospital · Participants: 2,000 · Started: 1994-07

Contact the study team

• Edwin K. Silverman, M.D., Ph.D. · Phone: 617-525-2128

Official record on ClinicalTrials.gov — NCT01177618

Locations in the U.S.

Conditions

• COPD
• Emphysema
• Chronic Bronchitis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.