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Studies of Neuregulin/ERBB Signaling in Human Heart

Isolation and Characterization of ERBB Expressing Human Heart Progenitor Cells

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Clinical diagnosis of severe coronary artery disease scheduled to undergo coronary artery bypass surgery.

Exclusion Criteria:

* less than 18 years of age
* unwilling or unable to provide informed consent
* known active myocarditis
* hypertrophic cardiomyopathy
* constrictive pericarditis or other significant pericardial disease
* severe pulmonary hypertension
* significant renal impairment (Cr \> 2.5 mg/dL)
* severe ventricular arrhythmias
* pregnancy

About the study

This study examines the role of the epidermal growth factor (EGF) receptor family and the EGF family of ligands in the regulation of non-myocytes isolated from the human heart.

Sponsor: Douglas B. Sawyer · Participants: 80 · Started: 2015-06

Contact the study team

Official record on ClinicalTrials.gov — NCT02820233

Locations in the U.S.

Conditions

• Heart Diseases
• Vascular Diseases
• Heart Failure

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.