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Heart Diseases clinical trials recruiting in the U.S.
73 studies for Heart Diseases are recruiting participants at sites across the United States.
Heart disease is the leading cause of death in the U.S. Learn about the different types of heart diseases, and what you can do to try to prevent them.
Cities with the most studies
- New York City, NY18 studies
- Boston, MA13 studies
- Cleveland, OH13 studies
- Los Angeles, CA12 studies
- Portland, OR11 studies
- Philadelphia, PA11 studies
- Atlanta, GA10 studies
- Dallas, TX10 studies
- Rochester, MN10 studies
- Durham, NC10 studies
- Chicago, IL10 studies
- Washington, DC9 studies
- Houston, TX9 studies
- Pittsburgh, PA9 studies
- Indianapolis, IN9 studies
- Phoenix, AZ9 studies
- Baltimore, MD9 studies
- Columbus, OH8 studies
- St. Louis, MO8 studies
- San Francisco, CA8 studies
- Cincinnati, OH8 studies
- San Diego, CA7 studies
- Nashville, TN7 studies
- Austin, TX7 studies
- Minneapolis, MN6 studies
- Charleston, SC6 studies
- Milwaukee, WI6 studies
- Newark, NJ6 studies
- Kansas City, KS5 studies
- Miami, FL4 studies
- Norfolk, VA4 studies
- New Rochelle, NY4 studies
- Louisville, KY4 studies
- Hartford, CT4 studies
- Kansas City, MO4 studies
- Arlington, VA4 studies
- Detroit, MI4 studies
- Salt Lake City, UT4 studies
- Naperville, IL4 studies
- Harrisburg, PA4 studies
By state
- Arizona9 studies
- California21 studies
- Colorado7 studies
- Connecticut5 studies
- District of Columbia8 studies
- Florida13 studies
- Georgia11 studies
- Illinois13 studies
- Indiana10 studies
- Iowa3 studies
- Kansas5 studies
- Kentucky4 studies
- Louisiana5 studies
- Maryland12 studies
- Massachusetts16 studies
- Michigan9 studies
- Minnesota16 studies
- Missouri11 studies
- Nebraska4 studies
- New Jersey9 studies
- New York20 studies
- North Carolina12 studies
- Ohio19 studies
- Oklahoma4 studies
- Oregon11 studies
- Pennsylvania15 studies
- South Carolina6 studies
- Tennessee9 studies
- Texas16 studies
- Utah6 studies
- Vermont3 studies
- Virginia9 studies
- Washington5 studies
- West Virginia3 studies
- Wisconsin7 studies
Recently updated studies
Safety and Effectiveness of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere VT)
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 29, 2026 · NCT07585968A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 28, 2026 · NCT07286578New Heart Imaging Techniques to Evaluate Possible Heart Disease
RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT01399385Capitalizing on AI to CapTure Undiagnosed Structural Heart Disease
Recruiting
Ages 40 and older · All sexes · Updated Sep 25, 2026 · NCT07843004Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
RecruitingObservational studyHealthy volunteers welcome
Ages 1 to 100 · All sexes · Updated Sep 22, 2026 · NCT01143454Personalized Environment and Genes Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT00341237Technical Development of Cardiovascular Magnetic Resonance Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 15, 2026 · NCT04927429Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.
Recruiting
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT03242642Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
Recruiting
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 3, 2026 · NCT06703489Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy
RecruitingPhase 2
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT07721025Clinical Course Of Disease In Participants With FA-CM
RecruitingObservational study
Ages 6 and older · All sexes · Updated Sep 2, 2026 · NCT06865482Abbott Structural Heart Device Registry
RecruitingObservational study
All ages · All sexes · Updated Sep 1, 2026 · NCT06590467Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions
Recruiting
Ages 18 to 80 · All sexes · Updated Aug 31, 2026 · NCT07258290A Preliminary Study for INFORMED
RecruitingPhase 4
Ages 65 and older · All sexes · Updated Aug 21, 2026 · NCT05585125A Study Of Heart Disease Using AI-Enabled Electrocardiography And Focused Cardiac Ultrasound
Recruiting
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT07351656Randomization of Single vs Multiple Arterial Grafts
Recruiting
Ages 18 to 70 · All sexes · Updated Aug 20, 2026 · NCT03217006Transition to KPL-387 Monotherapy Dosing & Administration Study
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Aug 11, 2026 · NCT07288216Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)
Recruiting
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT07130994Ask Questions About Clinical Trials
Recruiting
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07343297Cardiac Clearance vs G60 Hip Frailty Index
RecruitingObservational study
Ages 60 and older · All sexes · Updated Aug 4, 2026 · NCT07490184Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Aug 4, 2026 · NCT06563895ELEVATE-HFpEF Clinical Study
Recruiting
Ages 40 and older · All sexes · Updated Aug 3, 2026 · NCT06678841Rectus Sheath Block in Cardiac Surgery
Recruiting
Ages 18 to 85 · All sexes · Updated Jul 31, 2026 · NCT05833048Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT06552637From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.