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Heart Diseases clinical trials recruiting in the U.S.

71 studies for Heart Diseases are recruiting participants at sites across the United States.

Heart disease is the leading cause of death in the U.S. Learn about the different types of heart diseases, and what you can do to try to prevent them.

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Recently updated studies

Abbott Structural Heart Device Registry

RecruitingObservational study
All ages · All sexes · Updated Nov 13, 2026 · NCT06590467

Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure

Recruiting
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT06552637

iPSC Repository of Pediatric Cardiovascular Disease

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Nov 12, 2026 · NCT05550324

A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure

RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Nov 12, 2026 · NCT07584967

Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts

RecruitingPhase 2
All ages · All sexes · Updated Nov 10, 2026 · NCT04467671

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06526195

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

RecruitingObservational studyHealthy volunteers welcome
Ages 1 to 100 · All sexes · Updated Nov 4, 2026 · NCT01143454

ELEVATE-HFpEF Clinical Study

Recruiting
Ages 40 and older · All sexes · Updated Nov 3, 2026 · NCT06678841

Transition to KPL-387 Monotherapy Dosing & Administration Study

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Oct 28, 2026 · NCT07288216

TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT07684313

Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.

RecruitingObservational study
Ages 18 to 79 · All sexes · Updated Oct 20, 2026 · NCT04703166

Lumason® Infusion vs. Bolus Administrations

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT06400004

Clinical Course Of Disease In Participants With FA-CM

RecruitingObservational study
Ages 6 and older · All sexes · Updated Oct 19, 2026 · NCT06865482

Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)

RecruitingObservational study
0 Months – 20 Years · All sexes · Updated Oct 16, 2026 · NCT05055830

PKP2-ACM Natural History Study

RecruitingObservational study
Ages 12 and older · All sexes · Updated Oct 14, 2026 · NCT06644742

American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

RecruitingObservational study
Ages 21 to 80 · All sexes · Updated Oct 13, 2026 · NCT04185844

Technical Development of Cardiovascular Magnetic Resonance Imaging

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 9, 2026 · NCT04927429

New Heart Imaging Techniques to Evaluate Possible Heart Disease

RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 7, 2026 · NCT01399385

Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border Regions

RecruitingHealthy volunteers welcome
Ages 6 and older · All sexes · Updated Oct 2, 2026 · NCT06596902

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.