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Heart Diseases clinical trials recruiting in the U.S.
71 studies for Heart Diseases are recruiting participants at sites across the United States.
Heart disease is the leading cause of death in the U.S. Learn about the different types of heart diseases, and what you can do to try to prevent them.
Cities with the most studies
- New York City, NY17 studies
- Boston, MA13 studies
- Dallas, TX12 studies
- Cleveland, OH12 studies
- Los Angeles, CA11 studies
- Philadelphia, PA11 studies
- Portland, OR10 studies
- Pittsburgh, PA10 studies
- Durham, NC10 studies
- Rochester, MN10 studies
- Indianapolis, IN10 studies
- St. Louis, MO9 studies
- Houston, TX9 studies
- San Francisco, CA9 studies
- Columbus, OH8 studies
- Phoenix, AZ8 studies
- Washington, DC8 studies
- Atlanta, GA8 studies
- Chicago, IL8 studies
- San Diego, CA7 studies
- Cincinnati, OH7 studies
- Austin, TX7 studies
- Baltimore, MD7 studies
- Nashville, TN7 studies
- Minneapolis, MN6 studies
- Charleston, SC5 studies
- Newark, NJ5 studies
- Milwaukee, WI5 studies
- Harrisburg, PA5 studies
- Tampa, FL5 studies
- Norfolk, VA4 studies
- Edison, NJ4 studies
- Miami, FL4 studies
- Sacramento, CA4 studies
- Detroit, MI4 studies
- Kansas City, KS4 studies
- Richmond, VA4 studies
- Naperville, IL4 studies
- Plano, TX4 studies
- Kansas City, MO4 studies
By state
- Arizona8 studies
- California22 studies
- Colorado7 studies
- Connecticut5 studies
- District of Columbia7 studies
- Florida14 studies
- Georgia9 studies
- Illinois12 studies
- Indiana12 studies
- Iowa3 studies
- Kansas4 studies
- Kentucky3 studies
- Louisiana3 studies
- Maryland10 studies
- Massachusetts16 studies
- Michigan8 studies
- Minnesota16 studies
- Missouri12 studies
- Nebraska3 studies
- New Jersey9 studies
- New Mexico3 studies
- New York19 studies
- North Carolina12 studies
- Ohio18 studies
- Oklahoma5 studies
- Oregon10 studies
- Pennsylvania16 studies
- South Carolina5 studies
- Tennessee8 studies
- Texas18 studies
- Utah6 studies
- Vermont3 studies
- Virginia9 studies
- Washington5 studies
- West Virginia3 studies
- Wisconsin6 studies
Recently updated studies
Abbott Structural Heart Device Registry
RecruitingObservational study
All ages · All sexes · Updated Nov 13, 2026 · NCT06590467Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT06552637iPSC Repository of Pediatric Cardiovascular Disease
RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Nov 12, 2026 · NCT05550324Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions
Recruiting
Ages 18 to 80 · All sexes · Updated Nov 12, 2026 · NCT07258290A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Nov 12, 2026 · NCT07584967INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
Recruiting
Ages 18 to 80 · All sexes · Updated Nov 12, 2026 · NCT06965504A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
Recruiting
Ages 18 to 85 · All sexes · Updated Nov 10, 2026 · NCT07286578Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts
RecruitingPhase 2
All ages · All sexes · Updated Nov 10, 2026 · NCT04467671Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06526195Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
RecruitingObservational studyHealthy volunteers welcome
Ages 1 to 100 · All sexes · Updated Nov 4, 2026 · NCT01143454ELEVATE-HFpEF Clinical Study
Recruiting
Ages 40 and older · All sexes · Updated Nov 3, 2026 · NCT06678841Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.
Recruiting
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT03242642Transition to KPL-387 Monotherapy Dosing & Administration Study
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Oct 28, 2026 · NCT07288216Understanding Decentralized Trial Engagement and Clinical Impediments Through Digital Efforts (UDECIDE) Among Unrepresented Groups With Poor Cardiovascular and Cardiometabolic Health
Recruiting
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06587204Safety and Effectiveness of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere VT)
Recruiting
Ages 18 to 85 · All sexes · Updated Oct 26, 2026 · NCT07585968TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study)
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT07684313Tulane iPredict, Prevent Study to Evaluate the Progression of Atrial Myopathy.
RecruitingObservational study
Ages 18 to 79 · All sexes · Updated Oct 20, 2026 · NCT04703166Lumason® Infusion vs. Bolus Administrations
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT06400004Clinical Course Of Disease In Participants With FA-CM
RecruitingObservational study
Ages 6 and older · All sexes · Updated Oct 19, 2026 · NCT06865482Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
RecruitingObservational study
0 Months – 20 Years · All sexes · Updated Oct 16, 2026 · NCT05055830PKP2-ACM Natural History Study
RecruitingObservational study
Ages 12 and older · All sexes · Updated Oct 14, 2026 · NCT06644742American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)
RecruitingObservational study
Ages 21 to 80 · All sexes · Updated Oct 13, 2026 · NCT04185844Technical Development of Cardiovascular Magnetic Resonance Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 9, 2026 · NCT04927429New Heart Imaging Techniques to Evaluate Possible Heart Disease
RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 7, 2026 · NCT01399385Promoting Physical Activity and Fitness Among Underserved Latino Families Living in U.S.-Mexico Border Regions
RecruitingHealthy volunteers welcome
Ages 6 and older · All sexes · Updated Oct 2, 2026 · NCT06596902From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.