Home › Heart Valve Diseases › NCT04126018
Comparative Imaging Assessment of Valvular Heart Disease
Assessment of Left Ventricular Volumes and Strain and Assessment of Valvular Lesions Using Two- and Three-dimensional Echocardiography and Cardiac MRI, a Correlation Study
Who can join
Ages 18 to 90 · All sexes
Full eligibility criteria
Inclusion Criteria: * Age 18-90 years of age * Suspected moderate or severe MR,AR or AS on the basis of prior known clinical history or clinical exam. * Suspected CRT "non-responder" with an implanted MRI compatible CRT device and reduced ejection fraction Exclusion Criteria: * Acute traumatic cardiac injury * Aortic dissection or aortic root rupture * Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD * Presence of A-V fistula or intracardiac shunts * Any contraindications to CMR * Moderate or severe dysfunction in multiple valves * Patients with significant claustrophobia
About the study
The purpose of the study is to compare the various 2D and 3D methods of valvular heart disease quantification (Doppler, PISA, VCA, volumetric method) and strain with cardiac magnetic resonance (CMR) measurements of left and right ventricular systolic function strain and myocardial fibrosis assessment.
What is being tested
- MRI with strain measurement (diagnostic test)
- Echocardiography (diagnostic test)
Sponsor: The Cleveland Clinic · Participants: 200 · Started: Aug 23, 2019
Contact the study team
- Deborah Kwon, M. D. · Phone: 216-444-8526
Official record on ClinicalTrials.gov — NCT04126018
Locations in the U.S.
| Ohio | Cleveland Clinic, Cleveland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.