Brain Connections for Arm Movement After Stroke

Inclusion Criteria:

Inclusion Criteria (control participants):

* Be 45-90 years of age
* Have adequate language and neurocognitive function to participate in training and testing
* Be medically stable to participate in the study
* Be English speaking

Inclusion Criteria (participants with stroke):

* Be 45-90 years of age
* Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis
* Stroke onset at least 6 months before enrollment
* Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
* Present with mild to moderate arm dysfunction
* Be medically stable to participate in the study
* Be English speaking

Exclusion Criteria:

(for both groups)

* Unable to give informed consent
* Have a serious complicating medical illness that would preclude participation
* Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
* Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor
* Unable to comply with requirements of the study
* Enrollment in another greater-than-minimal risk study
* Presence of medical condition or implant that prevents safe administration of TMS or MRI
* Pregnancy