Home › Inflammatory Bowel Disease › NCT04508088
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
Who can join
Ages 13 to 20 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Crohn's Disease diagnosed within the past 3 months, or a healthy, matched control Exclusion Criteria: * Participants with chronic disease known to affect skeletal metabolism * Participants on certain medications within the prior 3 months that are known to affect skeletal metabolism * Participants who are pregnant * Participants who have a history of: claustrophobia, internal body metal that is not compatible with MRI machine, or a known abnormality on or adjacent to the left knee
About the study
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with newly diagnosed CD exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including bone turnover markers and immune cellular/molecular parameters.
What is being tested
- Coronal T1 weighted spin echo images (diagnostic test)
- Spin-lattice relaxation (T1) (diagnostic test)
- Magnetic resonance spectroscopy (diagnostic test)
- Blood Draw (diagnostic test)
Sponsor: Massachusetts General Hospital · Participants: 92 · Started: Sep 10, 2020
Contact the study team
- Rebecca Gordon, MD · Phone: (617) 355-7476
Official record on ClinicalTrials.gov — NCT04508088
Locations in the U.S.
| Massachusetts | Boston Children's Hospital, Boston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.