Localizing Epileptic Networks Using MRI and iEEG
Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Patients with medication-refractory epilepsy * Planned intracranial EEG (IEEG) placement * Hypothesized to have temporal lobe epilepsy Exclusion Criteria: * Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)
About the study
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.
What is being tested
- 3T Magnetic Resonance Imaging (diagnostic test)
- Intracranial electroencephalography recordings (diagnostic test)
- 7T Magnetic Resonance Imaging (diagnostic test)
Sponsor: University of Pennsylvania · Participants: 290 · Started: Mar 1, 2021
Contact the study team
- Kathryn A Davis, MD, MSTR · Phone: 215-349-5166
Official record on ClinicalTrials.gov — NCT04649008
Locations in the U.S.
| Pennsylvania | University of Pennsylvania, Philadelphia |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.