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Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

Who can join

Ages 30 to 55 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Sedentary (defined as less than 1 hour per week of physical activity)
* BMI: 25-40
* Men and women with and without type 2 diabetes

Exclusion Criteria:

* Documented cardiovascular disease
* Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
* Obstructive pulmonary disease or asthma
* Peripheral neuropathy
* Physical impairment that would limit exercise ability
* Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
* Current or past smoking within the last 1 years
* Current tobacco use
* Anemia
* Control HbA1c \> 5.7, T2DM HbA1c \> 9
* Pregnant, nursing or hormonal therapy (other than contraceptives)
* Peri or post-menopausal women
* Type 1 diabetes
* Hepatic or renal disease.

About the study

The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.

What is being tested

• Cardiovascular exercise (behavioral)

Sponsor: University of Colorado, Denver · Participants: 150 · Started: Jun 17, 2022

Contact the study team

• Benjamin Juckett, MS · Phone: 303-724-1338

Official record on ClinicalTrials.gov — NCT04791371

Locations in the U.S.

Conditions

• Type 2 Diabetes
• Overweight
• Obesity

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.