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Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke

Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke (TRAINS): Neuromodulatory Intervention to Ameliorate Cognition After Stroke for Individuals At Risk for VCID.

Who can join

Ages 18 to 90 · All sexes

Inclusion Criteria:

* Stroke that occurred within 4 weeks of the study
* Presence of cognitive impairment attributable to stroke
* Between the ages of 18 and 90
* Able to understand the nature of the study and give informed consent
* Able to follow simple commands as evidenced by NIHSS subtest 1C =0

Exclusion Criteria

* History of chronic, serious, or unstable neurologic illness other than stroke
* Current unstable medical illness(es)
* History of reoccurring seizures or epilepsy
* Current abuse of alcohol or drugs (prescription or otherwise)
* Active and severe psychiatric disorder
* Metallic objects in the face or head other than dental apparatus such as braces, fillings, and implants.
* Pregnancy

About the study

The purpose of this study is to determine whether a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), combined with traditional cognitive therapy will improve cognitive function in patients with subacute stroke.

What is being tested

• tDCS (device)
• sham tDCS (device)
• Cognitive Therapy (behavioral)

Sponsor: University of Pennsylvania · Participants: 70 · Started: Sep 21, 2021

Contact the study team

• Daniela Sacchetti, MS · Phone: 215-572-8485

Official record on ClinicalTrials.gov — NCT04897334

Locations in the U.S.

Conditions

• Ischemic Stroke
• Mild Cognitive Impairment

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.