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Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
Who can join
Ages 18 to 55 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: 1. 18-55 years old 2. Experienced a psychotic disorder or mood disorder Exclusion Criteria: 1. Any neurological disorder or current substance use disorder (during the past 6 months) 2. Not proficient in English 3. A recent change in medication, or an acute symptom presentation 4. Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).
About the study
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.
What is being tested
- EMA (behavioral)
Sponsor: Massachusetts General Hospital · Participants: 120 · Started: Jul 13, 2022
Contact the study team
- Daphne J Holt, MD, PhD · Phone: 617-726-7618
Official record on ClinicalTrials.gov — NCT04940663
Locations in the U.S.
| Massachusetts | Massachusetts General Hospital, Charlestown |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.