Home › Schizophrenia › NCT05343598

Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia

Empirical Validation of a Cerebellar-cortical Hallucination Circuit

Who can join

Ages 18 to 55 · All sexes

Inclusion Criteria:

* Diagnosis of schizophrenia or schizoaffective disorder

Exclusion Criteria:

* substance use disorder in past 3 months
* ambidexterity
* contraindications for TMS or MRI including :
* history of neurological disorder
* history of head trauma resulting in loss of consciousness
* history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy
* metal in brain or skull
* implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt
* claustrophobic in MRI

About the study

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study how hallucinations work in schizophrenia.

TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study the investigators will be stimulating the brain to learn more about how TMS might improve these symptoms of schizophrenia.

What is being tested

• Repetitive Transcranial Magnetic Stimulation (rTMS) (device)
• Sham Repetitive Transcranial Magnetic Stimulation (rTMS) (device)

Sponsor: Mclean Hospital · Participants: 68 · Started: Oct 13, 2021

Contact the study team

Official record on ClinicalTrials.gov — NCT05343598

Locations in the U.S.

Conditions

• Schizophrenia
• Psychotic Disorders

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.