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Valuation in Depressed Mood, Anhedonia, and Anxiety

Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix

Who can join

Ages 25 to 50 · All sexes

Inclusion Criteria:

* mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

Exclusion Criteria:

* history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

About the study

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

What is being tested

• cognitive behavioral therapy (behavioral)
• valuation with instruction (behavioral)
• valuation without instruction (behavioral)

Sponsor: Virginia Polytechnic Institute and State University · Participants: 252 · Started: Aug 1, 2021

Contact the study team

Official record on ClinicalTrials.gov — NCT05384158

Locations in the U.S.

Conditions

• Depression
• Anxiety
• Anhedonia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.