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Cannabis' Impact on Alcohol Consumption
Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods
Who can join
Ages 21 to 50 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Age 21 to 50 * English-speaking * cannabis smoking in past two months * heavy drinking in past two months * in good physical health and weighing \< 250 lbs * zero breath alcohol at each visit Exclusion Criteria: * positive pregnancy test * nursing * positive urine toxicology screen for drugs other than cannabis * interest to quit or receive treatment for cannabis or alcohol use
About the study
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement for drinks not consumed. Cannabis will be administered simultaneously with an alcohol-priming dose or alcohol placebo.
The study will enroll up to 350 nontreatment-seeking heavy episodic alcohol drinkers who use cannabis weekly.
What is being tested
- THC-dominant cannabis (drug)
- CBD-dominant cannabis (drug)
- Cannabis placebo (drug)
- Alcohol (drug)
- Alcohol placebo (drug)
Sponsor: Brown University · Participants: 350 · Started: Mar 16, 2023
Contact the study team
- Jane Metrik, PhD · Phone: 401-863-6650
Official record on ClinicalTrials.gov — NCT05389930
Locations in the U.S.
| Rhode Island | Brown University, Providence |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.