Home › Ischemic Stroke › NCT05703386

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Clinical or radiographic evidence of ischemic stroke
* One vascular risk factor (hypertension, hyperlipidemia, or diabetes)
* Evidence of cerebral small vessel disease on MRI

Exclusion Criteria:

* Inability to complete 3 research MRI scans over 1.25 years

About the study

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Sponsor: Johns Hopkins University · Participants: 50 · Started: Nov 8, 2022

Contact the study team

• Sera Chase · Phone: 410-502-5355

Official record on ClinicalTrials.gov — NCT05703386

Locations in the U.S.

Conditions

• Ischemic Stroke
• High Blood Pressure
• Hyperlipidemias
• Diabetes
• Dementia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.