Cardiovascular Effects of Very Low Nicotine Content Cigarettes
RecruitingEarly phase 1Healthy volunteers welcome
Who can join
Ages 21 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Self-reported cigarette smoking at least once in the past 30 days * ≥21 years old * Willingness to smoke research cigarettes or usual brand cigarettes during lab visit. * Ability to speak, comprehend, and read English sufficiently to complete study procedures Exclusion Criteria: * Self-reported diagnosis of cardiovascular diseases like coronary artery disease, stroke, peripheral artery disease, cardiac arrhythmia, pulmonary embolism \& blood clots in legs and arm in the past 3 months * Body temperature ≥ 100.4˙F * Unstable health conditions interfering with electrocardiogram (ECG) measurements * Self-reported diagnosis of hyperthyroidism or thyrotoxicosis * Currently pregnant (as indicated by urine pregnancy test at the start of laboratory visit) or breastfeeding. * Currently seeking treatment to quit smoking
About the study
The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers
What is being tested
- SPECTRUM cigarettes (drug)
- usual brand of Cigarettes (other)
Sponsor: Wake Forest University Health Sciences · Participants: 49 · Started: Apr 4, 2023
Contact the study team
- Maria Anwar, MS · Phone: 802-922-3343
Official record on ClinicalTrials.gov — NCT05707871
Locations in the U.S.
| North Carolina | Wake Forest University Health Sciences, Winston-Salem |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.