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Microbiome in Head and Neck Squamous Cell Carcinoma

Role of Human Microbiome in Head and Neck Cancer

Who can join

Ages 18 to 100 · All sexes

Inclusion Criteria:

1. Subjects equal to or above the age of 18.
2. Patients who are seen and evaluated by a provider within the adult Otolaryngology clinic at the University of Colorado Health.
3. Patients that present with a diagnosis of OSCC.
4. An equal number of age-matched patients who are visiting the clinic for reasons other than OSCC diagnoses, as the control group.
5. Ability to understand and willingness to sign a written informed consent document

Exclusion Criteria:

1. Subjects under the age of 18 or over the age of 100
2. Subjects unwilling to particiapte

About the study

This study aims to determine whether dysbiosis actively contributes to HNSCC and if so, the underlying molecular mechanisms.

What is being tested

• Metagenomic sequencing (diagnostic test)
• Metabolic analysis (diagnostic test)

Sponsor: University of Colorado, Denver · Participants: 60 · Started: May 23, 2025

Contact the study team

• Yosr Doghri · Phone: (303) 724-6550
• Kristi Engle Folchert · Phone: (303) 724-9528

Official record on ClinicalTrials.gov — NCT05837221

Locations in the U.S.

Conditions

• Head and Neck Cancer
• Oral Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.