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Impact of Bright Light Therapy on Prader-Willi Syndrome

A Randomized, Double-Blind, Controlled Trial of Bright Light Therapy on All-Cause Excessive Daytime Sleepiness in Prader-Willi Syndrome

Who can join

Ages 6 to 88 · All sexes

Inclusion Criteria:

* Diagnosis of PWS confirmed by genetic testing
* Score of 12 or above on the Epworth Sleepiness Scale (ESS).

Exclusion Criteria:

* Subjects with an eye condition that could be negatively affected by bright light such as patients with a history of retinal damage or patients needing photosensitizing medications
* A history of previous treatment with LT
* Patients presenting with active psychosis or mania

About the study

This is a placebo controlled clinical trial to assess the utility of light therapy as a sufficient treatment for excessive daytime sleepiness in patients with Prader-Willi Syndrome

What is being tested

• Sham Light (other)
• Bright Light Therapy (other)

Sponsor: Maimonides Medical Center · Participants: 50 · Started: Oct 1, 2023

Contact the study team

• Mayank Kumar, PhD · Phone: 718-283-8170
• Theresa Jacob, MPH, PhD · Phone: 718-283-7162

Official record on ClinicalTrials.gov — NCT05939453

Locations in the U.S.

Conditions

• Prader-Willi Syndrome
• Disorders of Excessive Somnolence
• Hyperphagia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.