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PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]

PET/CT vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Male or female patients
* 18 years or older
* referred for coronary CT angiography because of suspected coronary heart disease (CHD) with stable symptoms

Exclusion Criteria:

* The patient has a history of coronary heart disease, defined by prior myocardial infarction or prior coronary artery revascularization.
* Pregnancy.
* Atrial fibrillation.
* Morbid obesity defines as a body mass index of \>40.
* The patient has any other clinically significant medical condition that in the opinion of the Investigator could impact the patient's ability to successfully complete the trial.

About the study

Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed tomography (NaF-PET/CT) with those of conventional and ultra-high-resolution-CT (UHR-CT) in patients with suspected coronary artery disease. For this purpose, the investigators plan to include 33 patients with symptoms concerning for CAD who have been referred for cardiac CT testing.

What is being tested

• PET/CT (diagnostic test)

Sponsor: Johns Hopkins University · Participants: 33 · Started: Jul 1, 2023

Contact the study team

• Armin A Zadeh, MD PhD MPH · Phone: 410-502-0549
• Tia Thomas, RN, BSN · Phone: 410-955-5000

Official record on ClinicalTrials.gov — NCT05994014

Locations in the U.S.

Conditions

• Coronary Artery Disease
• Atherosclerosis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.