Home › Major Depressive Disorder › NCT05996900

Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans

Who can join

Ages 18 to 65 · All sexes

Inclusion Criteria:

* Men and women, ages 18 to 65
* Medication-refractory epilepsy requiring phase II monitoring
* Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent
* No current or history of major neurological disorders other than epilepsy

Exclusion Criteria:

* Those with a contraindication for MRIs (e.g. implanted metal)
* Any unstable medical condition
* Neurological or uncontrolled medical disease
* Active substance abuse
* Currently pregnant or breastfeeding

About the study

Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain's response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve the understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders.

What is being tested

• Intracranial electrodes (device)
• TMS (device)

Sponsor: Stanford University · Participants: 49 · Started: Sep 1, 2023

Contact the study team

• Jade Truong · Phone: (408) 840-3313

Official record on ClinicalTrials.gov — NCT05996900

Locations in the U.S.

Conditions

• Major Depressive Disorder
• Epilepsy

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.