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The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

Who can join

Ages 21 to 65 · All sexes

Inclusion Criteria:

* Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) diagnosis of Alcohol Use Disorder
* Medically healthy
* Ability to provide consent

Exclusion Criteria:

* Unstable medical conditions

About the study

This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.

What is being tested

• 0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion (drug)
• 0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion (drug)
• 25 mg Diphenhydramine (5 min) + Normal Saline (drug)

Sponsor: Yale University · Participants: 63 · Started: Aug 4, 2025

Contact the study team

• Angelina Contreras · Phone: (203) 974-7525

Official record on ClinicalTrials.gov — NCT06070649

Locations in the U.S.

Conditions

• Alcohol Use Disorder (AUD)
• Alcohol Use Disorder (AUD) Treatment
• Alcohol

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.