Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol
Who can join
Ages 21 to 55 · All sexes
Full eligibility criteria
Inclusion Criteria: * age 21-55 * fluent in English * diagnosis of mood, anxiety, or traumatic stress disorder * clinically elevated repetitive negative thinking * outpatient status * 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications Exclusion Criteria: * past year diagnosis of severe alcohol or moderate or greater substance use disorder * lifetime history of psychotic or bipolar I disorder * acute suicidality necessitating immediate clinical intervention * neurodegenerative or neurodevelopmental disorders * history of moderate or severe traumatic brain injury or other known neurological condition * sensory deficits that would preclude completing tasks * conditions unsafe for completing MRI scanning (e.g., metal in body) * current pregnancy * currently receiving psychosocial treatment * currently receiving psychiatric pharmacotherapy, except SSRIs
About the study
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.
What is being tested
- COGENT (behavioral)
- Sham Program (other)
Sponsor: University of California, San Diego · Participants: 128 · Started: Oct 1, 2024
Contact the study team
- Jessica Bomyea, Ph.D. · Phone: 858.552.8585
Official record on ClinicalTrials.gov — NCT06273527
Locations in the U.S.
| California | UC San Diego, San Diego |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.