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Early Detection of Advanced Adenomas and Colorectal Cancer

A Liquid Biopsy Assay For The Non-Invasive Early Detection of Advanced Adenomas and Colorectal Cancer

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* All individuals included in the study need to have had a colonoscopy at the time of blood sampling.
* Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
* Received standard pathological and endoscopic diagnosis and assessment for cohort assignment.

Exclusion Criteria:

* Hereditary colorectal cancer syndromes (identified through genetic testing).
* Inflammatory bowel diseases.
* Lack of written informed consent.

About the study

This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

What is being tested

• DENEB (diagnostic test)

Sponsor: City of Hope Medical Center · Participants: 2,000 · Started: Mar 15, 2020

Contact the study team

• Ajay Goel, PhD · Phone: 6262183452

Official record on ClinicalTrials.gov — NCT06342440

Locations in the U.S.

Conditions

• Colorectal Cancer
• Colon Cancer

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.