Warrior CARE: Cannabis Behavioral Health

Inclusion Criteria:

* a healthy veteran who has served in a branch of the US armed forces
* report using cannabis within the past year
* currently meet DSM-5 criteria for PTSD and a score of 25 or greater on the CAPS-5 (the anchor, or index, trauma does not have to be related to military service)
* between the ages of 19-69 years old
* not seeking treatment for Cannabis Use Disorder
* stable (i.e., under the care of a physician or therapist and not experiencing acute symptoms) on psychotropic medications and/or psychotherapy before the study begins (participants can be in treatment for PTSD)
* agree to adhere to study procedures

Exclusion Criteria:

* pregnant, lactating, or heterosexually active women and not using medically approved birth control
* current or past bipolar or psychotic disorder as determined using the SCID-5
* at immediate high risk for suicide based on the C-SSRS
* current SUD other than Nicotine Use Disorder and Alcohol Use Disorder (mild or moderate)
* allergies and/or other contradictions for using cannabis
* any clinically significant medical problems
* systolic/diastolic BP \>140/90 mmHg or systolic BP \<95 mmHg
* elevated liver function tests
* exhibit cognitive impairment (\<80 IQ)
* enrolled in another clinical trial or have received any drug as part of a research study within 30 days of dosing
* used a prescription medication (with the exception of birth control) within 14 days of study entry that in the opinion of the medically responsible investigator will interfere with the safety of the participant or the study results
* unable to provide informed consent