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Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Age ≥ 18
* English speaking
* Surgical or procedural patient who will be admitted postoperatively
* Willingness to answer psychosocial survey and/or audio recorded semi-structured interview

Exclusion Criteria:

-Cognitive dysfunction that precludes communication

About the study

The goal of this observational study is to learn about how regional anesthesia (numbing medication) affects pain in patients with different psychosocial phenotypes such as different levels of concern about pain, sleep issues, and anxiety, who are having surgery.

The main questions are:

1. Do psychosocial factors such as concerns about pain, sleep, anxiety affect the effectiveness of regional anesthesia? 2. Do psychosocial factors and regional anesthesia affect the amount of opioids used after surgery? 3. Do psychosocial factors and regional anesthesia affect development of chronic postsurgical pain?

What is being tested

• regional anesthesia (procedure)
• no regional anesthesia (procedure)
• acute pain consultation (other)
• no acute pain consultation (other)

Sponsor: Brigham and Women's Hospital · Participants: 1,000 · Started: Jul 3, 2024

Contact the study team

• Yun-Yun K Chen, MD · Phone: 617-651-0932

Official record on ClinicalTrials.gov — NCT06466941

Locations in the U.S.

Conditions

• Acute Pain
• Pain After Surgery

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.