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Pericardiotomy in Cardiac Surgery

Pericardiotomy in Cardiac Surgery Trial

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Patients greater than or equal to 18 years of age
* Requiring surgical intervention on the proximal aorta, cardiac valves, and/or coronary arteries
* Able to provide informed consent

Exclusion Criteria:

* History of atrial fibrillation or flutter
* Cardiac surgery procedures not included in the inclusion criteria (planned ventricular assistance device, aortic arch, transplantation surgery)
* Prior cardiac surgery requiring opening of the pericardium
* Previous surgical instrumentation of the left pleural cavity
* Patient undergoing minimally invasive cardiac surgery

About the study

PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.

What is being tested

• Left Posterior Pericardiotomy (procedure)

Sponsor: Population Health Research Institute · Participants: 1,400 · Started: Oct 21, 2024

Contact the study team

• Richard Whitlock · Phone: 9055274322

Official record on ClinicalTrials.gov — NCT06486636

Locations in the U.S.

Conditions

• Atrial Fibrillation
• Atrial Flutter
• Cardiovascular Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.