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Eccentric Exercise and Fatigue in Multiple Sclerosis

The Effect of Lower Extremity Eccentric Resistance Training on Fatigue in Multiple Sclerosis

Who can join

Ages 18 to 75 · All sexes

Inclusion Criteria:

* Definitive diagnosis of Multiple Sclerosis.
* Ability to walk for 6 minutes continuously with or without assistive device
* Ability read, understand and sign and informed consent

Exclusion Criteria:

* Evidence of recent exacerbation in the last 2 months prior to starting the study
* Orthopedic, cardiopulmonary, or non -MS neurologic condition that could interfere with carrying out the study protocol

About the study

The goal of this observational study is to compare the impact of eccentric resistance training to traditional resistance training on fatigue in persons with multiple sclerosis (MS). The primary question this study is asking is the following: is eccentric resistance training more fatiguing than traditional resistance training in persons with MS?. Participants will be asked to come for two sessions for two weeks. In the first week, subjects will undergo a bout of either traditional or eccentric resistance training. The next day they will return to assess their level of fatigue. The following week the subject will return and undergo whatever type of training they did not experience the first week, and it's effects on fatigue will again be assessed. The difference between the subjects level of fatigue for either condition will be compared.

What is being tested

• Resistance training (behavioral)

Sponsor: Hunter College of City University of New York · Participants: 30 · Started: Jul 1, 2024

Contact the study team

• Herbert Karpatkin, DSc · Phone: 212-396-7115

Official record on ClinicalTrials.gov — NCT06505421

Locations in the U.S.

Conditions

• Multiple Sclerosis
• Fatigue

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.