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Night Owl Metabolism
Night Owl Metabolism: Investigating the Impact of Chronotype on Glucose Metabolism in Youth
Who can join
Ages 18 to 23 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Overweight similar to (BMI ≥ 85th percentile but \<95th percentile for age and sex per Centers for Disease Control and Prevention growth curves (as Centers for Disease Control and Prevention growth curves contain ages ≤ 20y; if ages 21-23 years, the BMI ≥ 85th and \<95th percentile equivalents for a 20-year-old will be used)) * Post-pubertal * Normal sleep duration (avg. \>7 hours of sleep per night) * Social jetlag (difference between weekend and weekday sleep) of \< 2 hours. Exclusion Criteria: * Known diabetes, sleep disorders, major organ system illness, pregnancy, or genetic syndrome * Medication use known to affect insulin sensitivity, glucose tolerance, or circadian rhythm * Screening high risk for obstructive sleep apnea * Night shift work.
About the study
The proposed study uses a novel and rigorous randomized cross-over study design in youth (18-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test (OGTT) or first-meal of day to a subject's chronotype. Both groups will undergo 2 OGTTs (aligned and mis-aligned with chronotype) to compare glucose tolerance and insulin sensitivity within-subject (primary outcome) and between groups (Aim 1). Then, youth will also undergo two standardized meals (aligned and mis-aligned with chronotype) while wearing continuous glucose monitoring to compare post-prandial glucose excursions within-subject and between groups (Aim 2). A pilot Exploratory Aim 3 (n=12 per group) will investigate delayed melatonin patterns under dim-light as a potential pathophysiologic mechanism behind abnormal glucose tolerance in youth with late chronotype on morning OGTTs.
What is being tested
- Timing of OGTT (diagnostic test)
- Timing of Standardized Meal (behavioral)
Sponsor: Johns Hopkins University · Participants: 70 · Started: Feb 25, 2025
Contact the study team
- Talia Hitt, MD/MPH/MSHP · Phone: 860-324-0072
Official record on ClinicalTrials.gov — NCT06507722
Locations in the U.S.
| Maryland | Johns Hopkins School of Medicine, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.