Home › Drug Use and Addiction › NCT06526286

Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

Who can join

Ages 12 to 89 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Primary care encounter AND
* Current opioid prescription (not buprenorphine) and Active opioid medications over the last 90 days OR
* Documented as on local Pain Registry "Does the patient fit the criteria to be included on the Pain Registry?" OR
* Has active problem list diagnosis of long-term (current) use of opiate analgesic OR
* Is taking \>=90 morphine milligram equivalents (MME) per day OR
* Prior positive toxicology screen for illicit drugs OR
* Diagnosis of opioid use disorder

Exclusion Criteria:

* Active cancer diagnosis in the last 1 year
* Hospice care/palliative care order
* Sickle cell disease diagnosis

About the study

The objective of this study is to evaluate the impact of clinical decision support (CDS) in the form of an alert to identify patients who may be at risk of opioid use disorder (OUD) and a clinical care pathway helping providers treating patients with opioid use disorder. The pathway provides health care providers with information and suggestions for screening and treatment of opioid use disorder, including treatment with medications. The 2022 Centers for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends providers asses for and treat opioid use disorder using approved medications for opioid use disorder (MOUD). This project will implement a passive CDS alert when a provider prescribes an opioid to a patient who may be at risk of opioid use disorder. Providers will also have link access to a clinical care pathway providing support for OUD screening and treatment. Before and after comparisons of buprenorphine (a medication used to treat opioid use disorder) prescribing by providers and outcomes of patients will be examined based on medical records data collected during routine care. The study period will be approximately 18 months.

What is being tested

• Medications for Opioid Use Disorder Pathway Clinical Decision Support (CDS) (other)

Sponsor: University of Colorado, Denver · Participants: 200,000 · Started: Jul 7, 2026

Contact the study team

• Heather Tolle, PhD · Phone: 303-724-9924

Official record on ClinicalTrials.gov — NCT06526286

Locations in the U.S.

Conditions

• Drug Use and Addiction
• Harm Reduction
• Opioid Overdose

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.