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Harm Reduction clinical trials recruiting in the U.S.

17 studies for Harm Reduction are recruiting participants at sites across the United States.

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Recently updated studies

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

Recruiting
Ages 21 and older · All sexes · Updated Sep 29, 2026 · NCT05815199

Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 89 · All sexes · Updated Sep 21, 2026 · NCT06526286

Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention

Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06843213

Shelter HArm Reduction Evaluation

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07170072

Harm Reduction Services

Recruiting
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05776316

Wellness, Alcohol, Vitals, and Emotions

Recruiting
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06982443

Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use

RecruitingHealthy volunteers welcome
Ages 21 to 55 · All sexes · Updated Jul 13, 2026 · NCT07698470

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Jun 11, 2026 · NCT07199517

Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

Recruiting
Ages 21 and older · All sexes · Updated May 18, 2026 · NCT06948058

Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

Recruiting
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06768814

Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes

RecruitingHealthy volunteers welcome
Ages 40 to 79 · All sexes · Updated Apr 21, 2026 · NCT05642715

Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Mar 16, 2026 · NCT06852170

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Mar 12, 2026 · NCT06372899

Harm Reduction for Smokers With Mental Illness

Recruiting
Ages 21 and older · All sexes · Updated Jan 15, 2026 · NCT06543407

Electronic Harm Reduction Treatment for Alcohol

RecruitingPhase 3
Ages 21 and older · All sexes · Updated Jul 8, 2025 · NCT06702007

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.