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Harm Reduction clinical trials recruiting in the U.S.
17 studies for Harm Reduction are recruiting participants at sites across the United States.
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Recently updated studies
E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness
Recruiting
Ages 21 and older · All sexes · Updated Sep 29, 2026 · NCT05815199Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 89 · All sexes · Updated Sep 21, 2026 · NCT06526286Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention
Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06843213Shelter HArm Reduction Evaluation
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07170072Harm Reduction Services
Recruiting
Ages 18 and older · All sexes · Updated Aug 20, 2026 · NCT05776316Wellness, Alcohol, Vitals, and Emotions
Recruiting
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06982443Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
RecruitingHealthy volunteers welcome
Ages 21 to 55 · All sexes · Updated Jul 13, 2026 · NCT07698470Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Jun 11, 2026 · NCT07199517Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy
Recruiting
Ages 21 and older · All sexes · Updated May 18, 2026 · NCT06948058Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
Recruiting
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06768814Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
RecruitingHealthy volunteers welcome
Ages 40 to 79 · All sexes · Updated Apr 21, 2026 · NCT05642715Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Mar 16, 2026 · NCT06852170Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
RecruitingHealthy volunteers welcome
Ages 21 and older · All sexes · Updated Mar 12, 2026 · NCT06372899Harm Reduction for Smokers With Mental Illness
Recruiting
Ages 21 and older · All sexes · Updated Jan 15, 2026 · NCT06543407A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students
Recruiting
Ages 9 to 22 · All sexes · Updated Oct 30, 2025 · NCT06115746Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs
Recruiting
Ages 18 and older · All sexes · Updated Aug 24, 2025 · NCT05800899Electronic Harm Reduction Treatment for Alcohol
RecruitingPhase 3
Ages 21 and older · All sexes · Updated Jul 8, 2025 · NCT06702007From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.