Home › Migraine › NCT06785129

Endometriosis and Migraine

Mechanisms Underlying Endometriosis and Migraine Comorbidity

Who can join

Ages 12 to 45 · Women · Healthy volunteers welcome

Inclusion Criteria:

1. Patients with diagnosed endometriosis, migraine, or both endometriosis and migraine
2. Healthy control subjects with no history of chronic pain
3. Age 12-45
4. Assigned female sex at birth

Exclusion Criteria:

1. Pregnancy or breastfeeding
2. Presence of prolactinoma
3. Presence of psychiatric, neurological, endocrinological and/or developmental conditions and taking medications for these conditions
4. Current use of dopamine agonist or SSRI medications
5. For patients aged 12-17 not having a parent/legal guardian willing to sign the consent and answer surveys about their child's health

About the study

This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples for hormone analyses.

What is being tested

• Thermal stimuli (device)
• Pressure stimuli (device)
• Pain ratings (behavioral)
• Conditioned pain modulation (CPM) response (behavioral)
• Hormonal assessment (biological)

Sponsor: Washington University School of Medicine · Participants: 120 · Started: Feb 12, 2025

Contact the study team

• Alana McMichael, MA · Phone: 314-273-6194

Official record on ClinicalTrials.gov — NCT06785129

Locations in the U.S.

Conditions

• Migraine
• Endometriosis
• Pain

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.