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Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

Recruiting

Who can join

Ages 21 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* body mass index (BMI) ≥ 30 kg/m2 (i.e., obese)
* smoked ≥ 5 cigarettes/day during the past year
* 21 or older (due to minimum legal age EC restrictions)
* exhaled breath carbon monoxide (CO) level \> 6 ppm at Baseline (BL) (to confirm self-reported smoking)
* willing to use EC or NRT for 8 weeks
* access to a Bluetooth-enabled smartphone/tablet (to permit remote measurement of CO and other outcome variables)

Exclusion Criteria:

* received smoking cessation treatment of any kind in the past 30 days (actively quitting smoking),
* currently using EC or NRT more than 2 days/week (this may affect responses to study-supplied products)
* hospitalized for mental illness in past 30 days
* heart-related event (e.g., heart attack, severe angina) in past 30 days
* residing with another person currently enrolled in the study
* pregnant, nursing, or planning to become pregnant in the next 6 months
* medical contraindication for study or product use (e.g., allergy to adhesives)
* taken prescription weight loss medication in the last 30 days

About the study

This project will investigate the effects of alternative nicotine products on smoking, weight gain, and related outcomes.

What is being tested

Sponsor: Brown University · Participants: 60 · Started: Apr 1, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT06948058

Locations in the U.S.

Rhode IslandBrown University, Providence

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.