Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain

Inclusion Criteria:

For healthy subjects to be eligible to participate in this study, an individual must meet all of the following criteria:

* Provide signed and dated informed consent form
* Willing to comply with all study procedures and be available for the duration of the study
* Male or female, at least 18 years of age
* In good general health as evidenced by medical history

For oral cancer patients to be eligible to participate in this study, an individual must meet all of the following criteria:

* Provide signed and dated informed consent form
* Willing to comply with all study procedures and be available for the duration of the study
* Male or female, at least 18 years of age
* Biopsy-proven squamous cell carcinoma (SCC) of the oral cavity that requires surgical resection
* Lesion is at least 1 cm in greatest surface dimension

Exclusion Criteria:

* Healthy subjects who meet any of the following criteria will be excluded from participation in this study:

  * Clinically and/or histologically proven oral pre-cancer, oral cancer
  * Pregnancy or lactation (Female subjects of child-bearing potential will have a rapid urine pregnancy test)
  * Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.

Oral cancer patients who meet any of the following criteria will be excluded from participation in this study:

* History of prior surgical, chemotherapeutic, or radiation treatment for head and neck cancer
* Pregnancy or lactation
* Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.

For participants with impaired kidney function (chronic kidney/renal disease) who wish to participate in the proposed research study, consultation with their primary care provider will be done prior to enrollment to determine safety