Probenecid Administration for Alcohol Craving and Consumption

Inclusion Criteria:

* • Male or female, ≥18 years.

  * women \>7 drinks/week; men \>14 drinks/week.
  * meet moderate to severe AUD score for DSM-5 criteria.
  * Breath Alcohol Content (BrAC)=0.00 at each visit.
  * in good health as confirmed by medical history, physical examination and lab tests.
  * willing to adhere to the study procedures.
  * understand informed consent and questionnaires in English at an 8th grade level.

Exclusion Criteria:

* • Women who are breastfeeding or positive urine test for pregnancy.

  * clinically significant medical abnormalities: unstable hypertension, clinically significant abnormal EKG, bilirubin \>150% of the upper normal limit, ALT/AST \>300% the UNL, creatinine clearance ≤60 dl/min
  * meet DSM-5 criteria for a diagnosis of schizophrenia, bipolar disorder, or other psychoses
  * medications that reduce alcohol consumption (naltrexone, disulfiram).
  * use aspirin (salicylates may reduce effect of probenecid), penicillin, methotrexate (may increase concentration).
  * history of suicide attempts in the last three years.
  * current diagnosis of a moderate or severe cannabis use disorder as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline.
  * current diagnosis of another substance disorder at any severity, other than nicotine, as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline.
  * current use of medications that may interact with probenecid.
  * history of hypersensitivity to sulfa drugs.