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The Better, Harder, Faster, Stronger Study

RecruitingObservational study

The BHFS Study (Better, Harder, Faster, Stronger): Does Neoadjuvant Chemotherapy Improve Fitness for Surgery?

Who can join

Ages 55 and older · Women

Full eligibility criteria
Inclusion Criteria:

* Ability to understand and willingness to sign an IRB-approved informed consent.
* Age \> 55 years at the time of enrollment.
* Newly diagnosed suspected ovarian/primary peritoneal/fallopian tube carcinoma of any histological subtype, FIGO Stage II-IV, per enrolling investigator, or newly diagnosed suspected endometrial carcinoma of any histologic subtype, FIGO Stage II-IV, per enrolling investigator.
* Planned for 3 or 4 cycles of NACT, with interval cytoreductive surgery planned thereafter.
* Ability to read, understand, and write the English language.
* As determined by the enrolling investigator, ability of the participant to understand and comply with study procedures for the entire length of the study.

Exclusion Criteria:

* History of brain metastases.
* History of poorly controlled psychiatric conditions, defined as hospitalization within the prior 3 months for psychiatric disorders, traumatic brain injury, cerebrovascular event, or dementia, per the enrolling investigator.
* Use of anti-amyloid agents, cholinesterase inhibitors, or Memantine for Alzheimers/cognitive impairment, at the time of enrollment.
* Vision impairment that would impede completion of study assessments, per enrolling investigator.

About the study

The purpose of this study is to evaluate changes in the electronic Frailty Index (eFI) score following 3-4 cycles of neoadjuvant chemotherapy (NACT) in participants with advanced ovarian and endometrial cancer.

What is being tested

Sponsor: Wake Forest University Health Sciences · Participants: 35 · Started: Jul 28, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07220512

Locations in the U.S.

North CarolinaWake Forest Baptist Comprehensive Cancer Center, Winston-Salem

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.