🔎 Trials Near Me

Home › Overweight › NCT07282600

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

RecruitingPhase 3

A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, and Type 2 Diabetes

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Have type 2 diabetes
* Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
* Have a BMI ≥ 27 kg/m2
* Have a stable body weight (\<5% body weight change) for 90 days prior to screening

Exclusion Criteria:

* Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
* Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
* Have type 1 diabetes
* Have taken any of the following antihyperglycemic medications within 90 days before screening:

  * amylin analogs
  * glucagon-like peptide-1 (GLP-1) receptor agonists
  * glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or
  * insulin
* Have had within 90 days prior to screening:

  * heart attack
  * stroke
  * coronary artery revascularization
  * unstable angina, or
  * hospitalization due to congestive heart failure
* Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
* Have taken medications or alternative remedies intended for weight loss within 90 days of screening

About the study

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.

What is being tested

Sponsor: Eli Lilly and Company · Participants: 1,035 · Started: Dec 15, 2025

Contact the study team

Official record on ClinicalTrials.gov — NCT07282600

Locations in the U.S.

AlabamaBirmingham Clinical Research, Birmingham
Cullman Clinical Trials, Cullman
ArizonaTucson Clinical Research Institute, Tucson
CaliforniaSan Fernando Valley Health Institute, Canoga Park
AMCR Institute, Escondido
NorCal Medical Research, Inc, Greenbrae
Ark Clinical Research, Long Beach
Pacific Clinical Studies, Los Alamitos
Inglewood Clinical, Los Angeles
Care Access - Santa Clarita, Santa Clarita
Encompass Clinical Research, Spring Valley
Diablo Clinical Research, Inc., Walnut Creek
ColoradoCare Access - Aurora, Aurora
ConnecticutNew England Research Associates, LLC, Bridgeport
CMR of Greater New Haven, LLC, Hamden
FloridaArrow Clinical Trials, Daytona Beach
Care Access - Delray Beach, Delray Beach
Fleming Island Center for Clinical Research, Fleming Island
Nature Coast Clinical Research - Inverness, Inverness
Jacksonville Center for Clinical Research, Jacksonville
Flourish Research Acquisition, LLC dba Flourish Research - North Miami, Miami
New Horizon Research Center, Miami
Adult Medicine of Lake County, Inc., Mt. Dora
American Research Centers of Florida, Pembroke Pines
Clinical Site Partners, LLC dba Flourish Research, Winter Park
GeorgiaTeak Research Consults - Dunwoody, Dunwoody
Teak Research Consults, Lawrenceville
The Jones Center Clinical Research, Macon
HawaiiPacific Diabetes & Endocrine Center, Honolulu
IllinoisNorthShore University Health System, Skokie
IndianaDM Clinical Research - Indianapolis, Indianapolis
LouisianaClinical Trials Management, LLC d/b/a Flourish Research, Metairie
IMA Clinical Research Monroe - Armand, Monroe
MarylandCentennial Medical Group, Columbia
MassachusettsLucida Clinical Trials, New Bedford
MissouriClinical Research Professionals, Chesterfield
Clinvest Headlands Llc, Springfield
New JerseyHypertension & Nephrology Association, Eatontown
IMA Clinical Research Warren, Warren Township
New MexicoAlbuquerque Clinical Trials, Inc., Albuquerque
New YorkNYC Research INC, Long Island City
North CarolinaPharmQuest Life Sciences, LLC, Greensboro
West Clinical Research, Morehead City
Trial Management Associates - Wilmington - Floral Parkway, Wilmington
North DakotaLillestol Research, Fargo
OhioCare Access - Lima, Lima
OregonSummit Headlands, Portland
PennsylvaniaPreferred Primary Care Physicians, Preferred Clinical Research-St. Clair, Pittsburgh
Preferred Primary Care Physicians, Uniontown
South CarolinaAccellacare - Mt Pleasant, Mt. Pleasant
TexasIMA Clinical Research Austin, Austin
Private Practice - Dr. Osvaldo A. Brusco, Corpus Christi
Velocity Clinical Research, Dallas, Dallas
Diabetes and Thyroid Center of Ft. Worth, Fort Worth
Juno Research, Houston
Southern Endocrinology Associates, Mesquite
Research Your Health, Plano
IMA Clinical Research San Antonio, San Antonio
UtahOgden Clinic - Canyon View, Ogden
Diabetes & Endocrine Treatment Specialists, Sandy City

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.