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A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
RecruitingPhase 3
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, and Type 2 Diabetes
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria:
* Have type 2 diabetes
* Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
* Have a BMI ≥ 27 kg/m2
* Have a stable body weight (\<5% body weight change) for 90 days prior to screening
Exclusion Criteria:
* Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
* Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
* Have type 1 diabetes
* Have taken any of the following antihyperglycemic medications within 90 days before screening:
* amylin analogs
* glucagon-like peptide-1 (GLP-1) receptor agonists
* glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or
* insulin
* Have had within 90 days prior to screening:
* heart attack
* stroke
* coronary artery revascularization
* unstable angina, or
* hospitalization due to congestive heart failure
* Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
* Have taken medications or alternative remedies intended for weight loss within 90 days of screening
About the study
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.
What is being tested
- Eloralintide (drug)
- Placebo (drug)
Sponsor: Eli Lilly and Company · Participants: 1,035 · Started: Dec 15, 2025
Contact the study team
- Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · Phone: 317-615-4559
Official record on ClinicalTrials.gov — NCT07282600
Locations in the U.S.
| Alabama | Birmingham Clinical Research, Birmingham Cullman Clinical Trials, Cullman |
| Arizona | Tucson Clinical Research Institute, Tucson |
| California | San Fernando Valley Health Institute, Canoga Park AMCR Institute, Escondido NorCal Medical Research, Inc, Greenbrae Ark Clinical Research, Long Beach Pacific Clinical Studies, Los Alamitos Inglewood Clinical, Los Angeles Care Access - Santa Clarita, Santa Clarita Encompass Clinical Research, Spring Valley Diablo Clinical Research, Inc., Walnut Creek |
| Colorado | Care Access - Aurora, Aurora |
| Connecticut | New England Research Associates, LLC, Bridgeport CMR of Greater New Haven, LLC, Hamden |
| Florida | Arrow Clinical Trials, Daytona Beach Care Access - Delray Beach, Delray Beach Fleming Island Center for Clinical Research, Fleming Island Nature Coast Clinical Research - Inverness, Inverness Jacksonville Center for Clinical Research, Jacksonville Flourish Research Acquisition, LLC dba Flourish Research - North Miami, Miami New Horizon Research Center, Miami Adult Medicine of Lake County, Inc., Mt. Dora American Research Centers of Florida, Pembroke Pines Clinical Site Partners, LLC dba Flourish Research, Winter Park |
| Georgia | Teak Research Consults - Dunwoody, Dunwoody Teak Research Consults, Lawrenceville The Jones Center Clinical Research, Macon |
| Hawaii | Pacific Diabetes & Endocrine Center, Honolulu |
| Illinois | NorthShore University Health System, Skokie |
| Indiana | DM Clinical Research - Indianapolis, Indianapolis |
| Louisiana | Clinical Trials Management, LLC d/b/a Flourish Research, Metairie IMA Clinical Research Monroe - Armand, Monroe |
| Maryland | Centennial Medical Group, Columbia |
| Massachusetts | Lucida Clinical Trials, New Bedford |
| Missouri | Clinical Research Professionals, Chesterfield Clinvest Headlands Llc, Springfield |
| New Jersey | Hypertension & Nephrology Association, Eatontown IMA Clinical Research Warren, Warren Township |
| New Mexico | Albuquerque Clinical Trials, Inc., Albuquerque |
| New York | NYC Research INC, Long Island City |
| North Carolina | PharmQuest Life Sciences, LLC, Greensboro West Clinical Research, Morehead City Trial Management Associates - Wilmington - Floral Parkway, Wilmington |
| North Dakota | Lillestol Research, Fargo |
| Ohio | Care Access - Lima, Lima |
| Oregon | Summit Headlands, Portland |
| Pennsylvania | Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair, Pittsburgh Preferred Primary Care Physicians, Uniontown |
| South Carolina | Accellacare - Mt Pleasant, Mt. Pleasant |
| Texas | IMA Clinical Research Austin, Austin Private Practice - Dr. Osvaldo A. Brusco, Corpus Christi Velocity Clinical Research, Dallas, Dallas Diabetes and Thyroid Center of Ft. Worth, Fort Worth Juno Research, Houston Southern Endocrinology Associates, Mesquite Research Your Health, Plano IMA Clinical Research San Antonio, San Antonio |
| Utah | Ogden Clinic - Canyon View, Ogden Diabetes & Endocrine Treatment Specialists, Sandy City |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.